Cross-over trial of the effect of a salt particle inhaler on pulmonary muco-ciliary cleansing in COPD patients as measured by lung scintigraphy.
Stable COPD patients will be examined twice with minimum two, maximum 14 days interval. In randomized order the patients will inhale from a salt particle inhaler with (active) or without (placebo) content.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
35
Inhalation from inhaler with (active) or without (placebo) content
Rigshospitalet, Clin nuclear and physiolog dept.
Copenhagen, Denmark
Muco-ciliary clearance
Retention of inhaled radioactive marker in percentage
Time frame: Activity at time zero
Muco-ciliary clearance
Retention of inhaled radioactive marker in percentage
Time frame: Activity at time 30 minutes
Muco-ciliary clearance
Retention of inhaled radioactive marker in percentage
Time frame: Activity at time 90 minutes
Muco-ciliary clearance
Retention of inhaled radioactive marker in percentage
Time frame: Activity at time 120 minutes
Registering number of coughs
Number of coughs during investigation is noted
Time frame: Activity at any time between time zero and 120 minutes
Collection of sputum
Sputum during investigation is collected for analysis of radioactivity content
Time frame: Activity at any time between time zero and 120 minutes
Symptoms in the subjects health
Subjective symptom description during last 24 hours is done by a CCQ (Clinical COPD Questionnaire)
Time frame: Activity at time zero
Symptoms in the subjects health
Subjective symptom description during investigation is done by a questionnaire
Time frame: Activity at time 30
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Symptoms in the subjects health
Subjective symptom description during investigation is done by a questionnaire
Time frame: Activity at time 120