Differences in Sitting Versus Standing on Metabolic and Cardiovascular Measurements

N/AEnrolling By InvitationNCT03927638

Montclair State University80 enrolled

Overview

This investigations examined the effect that posture has on metabolic and cardiovascular measurements. Further, it will explore the potential for body weight status or physical activity to influence these relationships. All subjects will complete a seated condition and a standing condition in a counterbalanced manner.

The purpose of the present study was to evaluate both metabolic and cardiovascular responses to acute bouts of computer work while sitting and standing. Cardiovascular measurements were made using continuous non-invasive blood pressure monitoring and metabolic measurements were made using indirect calorimetry. Subjects will be grouped and analyzed based upon the weight status of the subject. All subjects will complete a seated condition and a standing condition in a counterbalanced manner. Investigators hypothesize that metabolic and cardiovascular responses will be elevated in the standing condition compared to sitting.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Overweight and Obesity

Interventions

sit/standBEHAVIORAL

Subjects will be asked to both sit and stand during a single trial.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: * healthy adult Exclusion Criteria: * Have a history of cancer, cardiac issues, hypertension, pulmonary disease, stroke, neurological or muscular dystrophy, uncontrolled diabetes, or any life threatening chronic conditions. * Are currently being treated for infectious mononucleosis, hepatitis, pneumonia, or other infectious diseases. * Are unable or unwilling to stand in one position continuously for 15-20 minutes at a time. * Use nicotine products, or non-contraceptive hormonal therapy (birth control is okay). * Are pregnant or trying to become pregnant. * Are not between 18 and 50 years of age.

Locations (1)

Montclair State University

Montclair, New Jersey, United States

Outcomes

Primary Outcomes

Heart Rate

Using human non-invasive blood pressure continuous monitoring placed on the middle finger of the non-dominant hand will be used to measure heart rate based upon beat-by-beat finger pressure.

Time frame: Approximately 15 minutes in each condition (sitting and standing)

Systolic Blood Pressure (SBP)

Using human non-invasive blood pressure continuous monitoring placed on the middle finger of the non-dominant hand will be used to measure SBP based upon beat-by-beat finger pressure.

Time frame: Approximately 15 minutes in each condition (sitting and standing)

Diastolic Blood Pressure (DBP)

Using human non-invasive blood pressure continuous monitoring placed on the middle finger of the non-dominant hand will be used to measure DBP based upon beat-by-beat finger pressure.

Time frame: Approximately 15 minutes in each condition (sitting and standing)

Oxygen Consumption

Oxygen consumption will be measured using indirect calorimetry.

Time frame: Approximately 15 minutes in each condition (sitting and standing)

Carbon Dioxide Production

Carbon Dioxide will be measured using indirect calorimetry.

Time frame: Approximately 15 minutes in each condition (sitting and standing)

Ventilation

Ventilation will be measured using indirect calorimetry.

Time frame: Approximately 15 minutes in each condition (sitting and standing)

Respiratory Exchange Ration (RER)

RER will be calculated using oxygen and carbon dioxide value measure from indirect calorimetry.

Data from ClinicalTrials.gov

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Secondary Outcomes

Height

Standard stadiometer will be used to measure height in meters.

Time frame: 1 minute

Weight

Standard scale will be used to measure weight in kilograms.

Time frame: 1 minute

Body Mass Index (BMI)

Height in meters and weight in kilograms will be used to calculate BMI using the formula BMI = kg/m\^2.

Time frame: 1 minute

Body Composition

Body composition will be measured using air displacement plethysmography.

Time frame: Approximately 15 minutes

Total Peripheral Resistance (TPR)

Using human non-invasive blood pressure continuous monitoring placed on the middle finger of the non-dominant hand will be uses to estimate TPR based upon beat-by-beat finger pressure.

Time frame: Approximately 15 minutes in each condition (sitting and standing)

Stroke Volume

Using human non-invasive blood pressure continuous monitoring placed on the middle finger of the non-dominant hand will be used to estimate TPR based upon beat-by-beat finger pressure.

Time frame: Approximately 15 minutes in each condition (sitting and standing)

Cardiac Output (Q)

Using human non-invasive blood pressure continuous monitoring placed on the middle finger of the non-dominant hand will be used to estimate Q based upon beat-by-beat finger pressure.

Time frame: Approximately 15 minutes in each condition (sitting and standing)

Muscle Oxygen Saturation

Using Near-inferred spectroscopy muscle oxygen consumption will be monitored.

Time frame: Approximately 15 minutes in each condition (sitting and standing)