This study compares safety and efficacy between repetitive hourly dose of oral misoprostol and two hourly dose oral regimens for cervical ripening and labor induction.
Misoprostol is an effective agent for the induction of labor.existing guidelines recommend oral misoprostol solution every two hours.However,more research is required to optimize the use of oral misoprostol solution for labor induction.The current study is to compare efficacy and safety of repetitive hourly dose of oral misoprostol solution with two hourly dose of oral misoprostol solution for cervical ripening and labor induction.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
150
This study will include 150 pregnant women who fulfill the inclusion criteria and will be subdivided in two groups. Group1 will receive repetitive hourly dose of oral misoprostol solution equal to 10 microgram up to 12 doses or regular uterine activity. Group2 will receive oral misoprostol solution every two hours as 20 microgram up to 6 doses or regular uterine activity.
Ain Shams University
Cairo, Cairo Governorate, Egypt
RECRUITINGMode of delivery
Successful vaginal delivery within 24 hours from starting induction of labor or cesarean section delivery after failed trial of induction.
Time frame: 24 hours from the first dose of induction till delivery
Adverse maternal outcomes
As uterine hyper stimulation,fever,vomiting,shivering,nausea
Time frame: in 24 hours
Adverse neonatal outcomes
As neonatal intensive care unit admission,non reassuring fetal heart rate
Time frame: 24 hours post partum
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