The brain protection effect of dexmedetomidine has been approved in several studies. Basically, the anti-inflammatory effects and reducing catecholamines are thought to be a main role of the protection effect. In many studies reported the advantage of dexmedetomidine as a substitution of other sedative drugs for anesthesia. The anesthesia of intra-cranial aneurysmal clipping operation commonly use intravenous anesthetic agents combined with inhalation anesthesia for neuroprotection, and mostly propofol is used. The aim of this study is to examine the effects of dexmedetomidine on serum inflammatory markers and research the hemodynamic stability of dexmedetomidine compared to propofol in aneurysmal clipping operation.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
DOUBLE
Enrollment
70
Dexmedetomidine 0.7 ug/kg/h with sevoflurane 0.5 MAC and remifentanil infusion are used throughout anesthesia period
Effect site concentration of propofol 1.5 ng/ml with sevoflurane 0.5 MAC and remifentanil infusion are used throughout anesthesia period
The concentration of inflammatory markers
CRP (mg/ml)
Time frame: Baseline: Before injection study drugs
The concentration of inflammatory markers
CRP (mg/ml)
Time frame: 1 minute after operation
The concentration of inflammatory markers
CRP (mg/ml)
Time frame: Day 1 after operation
The concentration of inflammatory markers
CRP (mg/ml)
Time frame: Day 2 after operation
The concentration of norepinephrine
NE (nmol/l)
Time frame: Baseline: Before injection study drugs
The concentration of norepinephrine
NE (nmol/l)
Time frame: 1 minute after operation
The concentration of norepinephrine
NE (nmol/l)
Time frame: Day 1 after operation
The concentration of norepinephrine
NE (nmol/l)
Time frame: Day 2 after operation
The concentration of inflammatory markers
IL-6, IL-8, IL-10 ,TNF-a (pg/ml)
Time frame: Baseline: Before injection study drugs
The concentration of inflammatory markers
IL-6, IL-8, IL-10 ,TNF-a (pg/ml)
Time frame: 1 minute after operation
The concentration of inflammatory markers
IL-6, IL-8, IL-10 ,TNF-a (pg/ml)
Time frame: Day 1 after operation
The concentration of inflammatory markers
IL-6, IL-8, IL-10 ,TNF-a (pg/ml)
Time frame: Day 2 after operation
The frequency of hypotension or hypertension
Time frame: during operation
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.