Impact of Body Mass Index on Serum Maternal and Fetal Magnesium Level

Assiut University400 enrolled

Overview

Magnesium sulphate is an inorganic salt with multiple therapeutic applications in medicine it has been widely utilized and studied on a diverse set of conditions such as asthma, cardiac arrhythmia and stroke. In pregnant women ,MgSo4 has been used in many cases such as for seizures prophylaxis in preeclampsia, tocolysis in preterm labour and for fetal neuroprotection in immenint preterm delivery.MgSo4 has been used as the standard drug for tocolysis in preterm labour and other drugs have been compared to it.

Study Type

OBSERVATIONAL

Enrollment

400

Conditions

Pre-Eclampsia

Interventions

Magnesium SulfateDRUG

4 gram MgSo4 diluted in 150 cc saline infused IV within 30 minutes as loading dose then the patient will receive the maintenance dose of 1gram MgSo4 per hour for 6 hours.

Eligibility

Sex: FEMALE

Medical Language ↔ Plain English

Inclusion criteria: pregnant women 34 weeks or less admitted to Women's Health Hospital with a diagnosis of : * sever preeclampsia. It is defined as 1- blood pressure 160/110 mmHg or more 2- proteinurea (+3 or more by dipstick) 3-HELLP syndrome * threatened preterm labour that will receive Magnesium Sulphate either for tocolysis or neuroprotection. Exclusion criteria: \- women with more than 34 weeks gestation and with any contraindication for Magnesium Sulphate intake like severe renal impairment or myasthenia gravis.

Locations (1)

Ahmed Abbas

Assiut, Cairo Governorate, Egypt

RECRUITING

Outcomes

Primary Outcomes

the percentage of women reaching the Mg therapeutic level.

the Mg therapeutic level of 4,8 mg/dl.

Time frame: 24 hours

Data from ClinicalTrials.gov

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