Type 1 diabetes mellitus is a chronic autoimmune disease, associated with an increased risk of cardiovascular diseases. The development of cardiomyopathy in type 1 diabetes, independent of hypertension and coronary heart disease, is still controversial. A possible mechanism for diabetic cardiomyopathy is autonomic dysfunction. This study aims to evaluate cardiac function and structure, and to relate them with autonomic dysfunction in type 1 diabetes.
Study Type
OBSERVATIONAL
Enrollment
80
HU/UFSC
Florianópolis, Santa Catarina, Brazil
Preclinical myocardial dysfunction
Incidence of patients with alteration in left ventricular myocardial strain (≤ 17% in absolute value).
Time frame: At patient inclusion.
Left ventricular diastolic dysfunction
Incidence of patients with signs of diastolic dysfunction: average E/e' ratio (abnormal when \> 14)
Time frame: At patient inclusion.
Left ventricular hypertrophy
Incidence of patients with LV mass by linear measurements \> 95 g/m2 if women and \> 115 g/m2 if men.
Time frame: At patient inclusion.
Left atrial dysfunction
Incidence of patients with abnormal reservoir strain (normal range: 38%-41%), or abnormal conduit strain (normal range: 21%-25%), or abnormal contractile strain (normal range: 16%-19%).
Time frame: At patient inclusion.
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