A prospective randomized study designed to compare the efficacy of transcervical vasopressin injection versus vaginal misoprostol in reducing intra -operative blood loss during hysteroscopic mymectomy .
This was a prospective, randomized, study on forty women with symptomatic submucous myoma presented mostly with bleeding and/or infertility scheduled for hysteroscopic myomectomy were randomized to groups (group A) 20 patients transcervical intramyoma vasopressin injection and (group B) 20patients with vaginal misoprostol is used .
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
40
prostaglandin E1 analogue vaginally inserted two hours before hystertsopic myomectomy to evaluate intraoperative blood loss and operative time needed for completion of myomectomy
one ampoule of vasopressin was diluted to 50 ml of normal saline, and 10 ml (4 units of vasopressin) was withdrawn in a syringe. Needle was inserted through the working channel of the hysteroscope until its tip was seen. The needle tip was pointed to the site of injection under hysteroscopic guidance during the whole injection technique. Aspiration was done first to avoid intravascular injection of vasopressin. The diluted solution was injected into the surface, especially to parts with dilated vasculature till they blanch.
intraoperative bleeding
subjective assessment of bleeding by the surgeon.
Time frame: start with the first resectoscope myoma cut till withdrawal of hysterscope through the cervix at the end of the procedure
operative time
time needed for completion of myomectomy procedure
Time frame: start with insertion of hysterscope through the cervix ends with withdrawal of hysterscopy through the cervix at the end of the procedure
haemoglobin and hematocrit deficit
haemoglobin and hematocrit values before and after myomectomy
Time frame: 24 hours before myomectomy and 24 hour after myomectomy
Degree of visual clarity
visual analogue scale straight horizontal line of fixed length, usually 100 mm and the ends are defined as the extreme limits of the parameter)
Time frame: start with the first resectoscope myoma cut till the completion of myoma resection
Fluid deficit
calculation the fluid deficit between in flow volume and outflow volume
Time frame: start with insertion of hysterscope through the cervix ends with withdrawal of hysterscopy through the cervix at the end pf the procedure
time need for cervical dilatation
time needed to dilate the cervix to admit the operative hysterescope
Time frame: start from grasping the cervix till insertion of hysterescope
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