Progesterone Supplementation in Threatened Abortion

Tanta University190 enrolled

Overview

To decide whether progesterone supplementation in threatened abortion is a sound practice.

This study was conducted at Obstetrics and Gynecology Department, Tanta University in the period from January 2018 to December 2018. Patients: Eligible patients (n=190) were randomly allocated into 2 groups; study group who will receive progesterone supplementation (Prog.group) and control group who will receive no treatment (place.group).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

190

Conditions

Threatened Abortion Progesterone Resistance

Interventions

ProgesteroneDRUG

received rectal progesterone suppositories 400 mg once daily

PlacebosDRUG

received placebo suppositories rectally once daily.

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * threatened abortion diagnosed by history and ultrasound examination * singleton * viable fetus * gestational age \< 20 weeks * closed normal length cervix. Exclusion Criteria: * short cervix \<2 cm Multiple pregnancy * dead fetus * open cervix ≥ 2cm * history of cervical surgery * refusal to participate.

Locations (1)

Ayman Shehata Dawood

Tanta, Egypt

Outcomes

Primary Outcomes

relief of pain

questionnaire fulfilled by patient with yes or no questions

Time frame: 3 weeks

completion of pregnancy beyond 20 weeks

passing the age 20 weeks

Time frame: 12 weeks

Stoppage of bleeding

Cessation of bleeding

Time frame: 3 weeks

Secondary Outcomes

abortion less than 20 weeks.

Abortion

Time frame: 12 weeks

Data from ClinicalTrials.gov

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