Following acute STEMI patients may have significant myocardial damage and subsequent heart failure. There is currently conflicting data regarding the benefit of remote ischemic conditioning to decrease the magnitude of infarction. Remote ischemic condition is a process where by repetitive intermittent limb ischemia is used to decrease the magnitude of myocardial damage caused by coronary artery occlusion and the subsequent reperfusion injury in STEMI patients. RemCon-STEMI is a multicenter randomized trial to test the impact of remote ischemic conditioning in acute STEMI.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
251
BP cuff inflation for 5 min and deflation for 5 mins with 4 cycles
Standard of care
Composite of all cause death
all cause death, cardiogenic shock or chf through 90 days
Time frame: 90 days
long term survival
survival
Time frame: up to 1 year
myocardial infarction size
mi size using peak elevation of cardiac biomarkers
Time frame: within 72 hours of hospital admission
ECG infarct size
QRS score on baseline and discharge ECGS
Time frame: with 10 days or hospital discharge whichever occurs first
Reperfusion
ST segment resolution 30 minutes post PCI
Time frame: within 24 hours of admission to hospital
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