Delirium is a common neurologic complication after cardiac surgery occuring in 30-50% of patients. The occurence of this complication is associated with worse outcomes, including prolonged length of stay in the ICU and hospital, increased morbidity and mortality. Considering great clinical significance of this complication, the search for early predictors of postoperative delirium remains an urgent task. The purpose of this prospective observational study is to test the hypothesis that metabolomic changes before and after cardiac surgery could be served as early predictors of this complication.
Study Type
OBSERVATIONAL
Enrollment
100
Blood will be collected in all patients blood before surgery and after surgery (postoperative day 1). Our study is based on a polar metabolomics profiling of plasma and/or serum using hybrid triple quadrupole mass spectrometer coupled with chromatographic system.
E. Meshalkin National Medical Research Center
Novosibirsk, Russia
RECRUITINGPostoperative delirium
Postoperative delirium will be diagnosed with CAM-ICU (confusion assessment method - intensive care unit)
Time frame: 5 days after surgery
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