Antibiotic therapy for early onset neonatal sepsis recommended by international guidelines and relevant studies is only kind of treatment regimen that penicillin G/ penicillin/ampicillin combined with gentamicin as the first-line treatment regimen. However, it is not applicable to the clinical practice in many countries and regions. We aim to study efficacy and safety of antibiotics in the treatment of early onset neonatal sepsis.
Study Type
OBSERVATIONAL
Enrollment
500
Efficacy and safety of antibiotics
Tianjin Central Hospital of Gynecology Obstetrics
Tianjin, Tianjin Municipality, China
RECRUITINGTreatment failure
* requiring additional courses of antibiotic therapy within 72 hours after ending initial antibiotic therapy and/or * progression of the illness, necessitating a change of antibiotic and/or * blood culture isolate reported resistant to the antibiotic.
Time frame: 72 hours after ending initial antibiotic therapy
Treatment duration
Duration of initial antibiotic therapy
Time frame: Through study completion, an average of 3 days
Duration of hospitalization
Duration of hospitalization of patients
Time frame: In the first month of patients' life
PD target
The time of free drug concentration exceeding the minimal inhibitory concentration (fT\>MIC)
Time frame: Through study completion, an average of 3 days
White blood cell count
White blood cell count in ×10\^9/L
Time frame: Through study completion, an average of 3 days
Procalcitonin
Procalcitonin in ng/mL
Time frame: Through study completion, an average of 3 days
C-reactive protein
C-reactive protein in mg/L
Time frame: Through study completion, an average of 3 days
Death
Death in the first month of life
Time frame: In the first month of patients' life
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Adverse events
Drug-related adverse events and serious adverse events
Time frame: Through study completion, an average of 3 days