Immune Non-inferiority and Safety of a Vi-DT Typhoid Conjugate Vaccine

Inclusion Criteria: 1. Healthy participants 6 months to 45 years of age at enrollment 2. Participants/Parents/LAR who have voluntarily given informed consent/assent 3. Participants/Parents/LAR willing to follow the study procedures of the study and available for the entire duration of the study Exclusion Criteria: 1. Child with a congenital abnormality 2. Subject concomitantly enrolled or scheduled to be enrolled in another trial 3. Known history of immune function disorders including immunodeficiency diseases (Known HIV infection or other immune function disorders) 4. Chronic use of systemic steroids (\>2 mg/kg/day or \>20 mg/day prednisone equivalent for periods exceeding 10 days), cytotoxic or other immunosuppressive drugs 5. Receipt of blood or blood-derived products in the past 3 months 6. Subject with a previously ascertained or suspected disease caused by S. Typhi 7. Subject who have had household contact with/and or intimate exposure to an individual with laboratory-confirmed S. Typhi 8. Individual who has previously received a typhoid vaccine 9. Subject who has received or is expected to receive other vaccines from 1 month prior to IP vaccination to Visit 4 (approx.1 month post IP) except PVC booster as per EPI schedule 10. Known history or allergy to vaccines or other medications 11. History of uncontrolled coagulopathy or blood disorders 12. Any abnormality or chronic disease which in the opinion of the investigator might be detrimental for the safety of the subject and interfere with the assessment of the study objectives 13. Any female participant who is lactating, pregnant\* or planning for pregnancy during the course of study period 14. Participants/Parents/LAR planning to move from the study area before the end of study period 15. As per Investigator's medical judgement individuals could be excluded from the study inspite of meeting all inclusion/exclusion criteria mentioned above Temporary Contraindication 16. Acute illness, in particular infectious disease or fever (axillary temperature ≥37.5°C), within three days prior to enrolment and vaccination. * Urine pregnancy test (UPT) will be performed in all married females prior to injection