Effect of Thyroid Hormone on Post-Myocardial Infarction Remodeling and Prognosis in STEMI Patients

Beijing Friendship Hospital250 enrolled

Overview

This study aims to determine whether thyroid hormone levels are predictive of cardiac remodeling following myocardial infarction and the prognosis in patients with STEMI receiving primary percutaneous coronary intervention.

Study Type

OBSERVATIONAL

Enrollment

250

Conditions

Thyroid Cardiac Remodeling, Ventricular STEMI

Interventions

Thyroid hormone levelsOTHER

This is an observational study. Exposure: Different thyroid hormone levels.

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * with a confirmed STEMI diagnosis * undergoing primary percutaneous coronary intervention (presenting \<12h after symptom onset) * patients agreed and provided informed consent Exclusion Criteria: * past history of myocardial infarction or percutaneous coronary intervention or coronary artery bypass graft * past history of heart failure (LVEF\<40%) or myocardiopathy or atrial fibrillation * past history of thyroid diseases, or were treated with amiodarone, dopamine, or corticosteroids before hospital admission * contraindicating to cardiac magnetic resonance imaging

Locations (1)

Beijing Friendship Hospital, Capital Medical University

Beijing, China

RECRUITING

Outcomes

Primary Outcomes

MACE (major adverse cardiovascular events)

cardiovascular death, re-infarction, revascularization, and stroke

Time frame: 12 months

Secondary Outcomes

adverse cardiac remodeling

a cut-off value of 12% change in left ventricular end-diastolic volume between the acute and follow-up magnetic resonance scans

Time frame: 6 months

all-cause death

death caused by all reason

Time frame: 12 months

Central Contacts

Hongwei Li

CONTACT

0086 10 63139780 lhw19656@sina.com

Data from ClinicalTrials.gov

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