Postoperative Nausea and Vomiting After Laparoscopic Cholecystectomy

Yeungnam University College of Medicine88 enrolled

Overview

In the present study, midazolam and palonosetron in combination were more effective than palonosetron alone in lowering the incidence and severity of postoperative nausea and vomiting in the initial 2 h after laparoscopic cholecystectomy. Postoperative clinical complications were not different in both groups.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Enrollment

Conditions

Postoperative Nausea Postoperative Vomiting

Interventions

midazolam and palonosetron groupDRUG

intravenous midazolam and palonosetron administraion as prevention of postoperative nausea and vomiting

palonosetron groupDRUG

intravenous palonosetron administraion as prevention of postoperative nausea and vomiting

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * The patients (aged 20 to 65 years) scheduled for laparoscopic cholecystectomy with American Society of Anesthesiologists (ASA) physical status classification of 1 or 2 Exclusion Criteria: * The patients with a history of allergy to any other drugs used in this study, gastrointestinal disorder, previous PONV, pregnant woman, breastfeeding woman, use of antiemetics within 24 hours or body mass index \> 30 kg/m2

Locations (1)

Eun kyung Choi

Daegu, Korea (the Republic Of), South Korea

Outcomes

Primary Outcomes

incidence of postoperative nausea and vomiting

0=none; 1=occur

Time frame: 24 hours after surgery

severity of postoperative nausea and vomiting

0 = absent; 1 = mild; 2 = moderate; 3 = severe

Time frame: 24 hours after surgery

Data from ClinicalTrials.gov

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