The application of acute Normovolemic Hemodilution in cardiac surgery can effectively reduce perioperative blood transfusion, reduce postoperative complications and mortality, and is a low-cost, operable and effective blood protection measure.For the application of Acute Normovolemic Hemodilution in heart surgery, we still face an urgent problem: to what extent can Acute Normovolemic Hemodilution achieve better "blood saving effect", that is, whether a large number of Acute Normovolemic Hemodilution can reduce perioperative blood transfusion to a greater extent.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
PREVENTION
Masking
NONE
Enrollment
74
Following induction of anesthesia, the volume of blood to be removed during Acute Normovolemic Hemodilution was calculated using an established formula:V=Weight（Kg）×12-15（mL/Kg）;Blood to be removed was capped at： Vmax=EVB×(Hi-Hf)/Hav（EBV= estimated blood volume （male:70mL/Kg，female:65mL/Kg）；Hi= initial hemoglobin ；Hf=target Hb（ 10g/dL ）；Hav= the average of the initial and minimal allowable hemoglobin）.Ensure the volume of removed blood does not exceed the upper limit and Hb ≥10g/dL after blood removed.
The second affiliated hospital of Zhejiang University
Hangzhou, Zhejiang, China
Enrollment rate of subjects
The percentage of patients who completed the study
Time frame: Through study completion，about 8 months
Completion rate of acute normovolemic hemodilution
The percentage of patients who complete large volume of acute normovolemic hemodilution
Time frame: Through study completion，about 8 months
Additional blood transfusion beyond transfusion protocol
Nonstandard blood transfusion
Time frame: Through study completion，about 8 months
Rate of perioperative blood transfusion
The percentage of red blood, fresh frozen plasma and platelet transfusion
Time frame: Through study completion，about 8 months
Rate of postoperative cardiac complications
Including myocardial infarction, heart failure, low cardiac output, pericardial tamponade, severe arrhythmia according to physical and laboratory examination
Time frame: Through study completion，about 8 months
Rate of postoperative pulmonary complications
Including moderate and massive pleural effusion, respiratory failure, re-intubation according to physical and laboratory examination
Time frame: Through study completion，about 8 months
Rate of postoperative neurological complication
Including cerebral hemorrhage, cerebral infarction according to physical and laboratory examination
Time frame: Through study completion，about 8 months
Rate of postoperative renal complication
Need renal replacement therapy
Time frame: Through study completion，about 8 months
Other severe complication
Including re-operation, re-admission of intensive care unit, multiple organ dysfunction, all cause death according to physical and laboratory examination and medical record
Time frame: Through study completion，about 8 months
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