Comparing the Prognosis of Lactate-directed and Goal-directed Therapy in Hyperthermic Intraperitoneal Chemotherapy.

Taipei Medical University WanFang Hospital

Overview

Hyperthermic intraperitoneal chemotherapy is a major surgery for tumor peritoneal metastasis. For anesthesiologist, the intra-operative fluid control is always a big challenge. We try to compare the prognosis of lactate-directed and goal-directed therapy. We expect to confirm the better prognosis of lactate-directed therapy.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Conditions

Organ Failure, Multiple

Interventions

Lactate-directed therapyOTHER

If the lactate level elevates, we transfuse pRBC to increase Hct\>30%. If Hct \>30%, dopamine infusion starts.

Goal-directed therapyOTHER

If SVV\>15%, transfuse lactate ringer/normal saline alternatively to keep SVV\<15%.

Eligibility

Sex: ALLMin age: 20 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients receiving hyperthermic intraperitoneal chemotherapy Exclusion Criteria: * Unable to set arterial line Severe liver or renal disease Severe heart disease Unconscious patients

Outcomes

Primary Outcomes

pulmonary complication

X-ray findings of airspace or interstitial opacity, lobar consolidation, or pleural effusions; severe respiratory failure requiring respiratory support

Time frame: 1 week

Secondary Outcomes

Renal complication

oliguria with urine output\<0.5 ml/kg/h for more than 4 h, creatinine increase\>30 % of preoperative values, dialysis

Time frame: 1 week

Data from ClinicalTrials.gov

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