This study is to find out the significance of gut-microbiota in acute stroke patients, including their neurological, radiological outcomes as well as their stroke mechanisms.
Patients who suffered from acute stroke and in hospitalization in Prince of Wales Hospital will be recruited in the study. After the informed consent, their first bowel opening will be collected for storage. They will also receive assessment by the stroke team at 3 and 6 months to determine their outcomes (NIHSS and mRS). Clinically and radiologically parameters including their degree of disability, imaging findings will also be collected to determine whether there are any correlations with the stool microbiota composition against matched individuals.
Study Type
OBSERVATIONAL
Enrollment
200
Chinese University of Hong Kong
Hong Kong, Hong Kong
RECRUITINGThe composition of gut-microbiota contributing neurological outcome between groups
Gene sequencing of the 16S rRNA on the stool samples are performed to identify the microbes down to genus level, as well as the microbrobiota diversity and relative abundance. And stroke etiology classified by TOAST Classification and disability indices (NIHSS \& mRS at baseline, 3 month \& 6 month) will be recorded.
Time frame: 31 Dec, 2020
The composition of gut-mircobiota contributing radiological finding between groups
Gene sequencing of the 16S rRNA on the stool samples are performed to identify the microbes down to genus level, as well as the microbrobiota diversity and relative abundance. All patients who received a plain CT brain \& MRI for the diagnosis of stroke will be reviewed. Infarct volume in DWI, MR angiography abnormalities, presence of microbleed and/or haemorrhagic transformation will be documented.
Time frame: 31 Dec, 2020
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