The Effect of Iloprost on Oxygenation During One-lung Ventilation for Lung Surgery

Seoul St. Mary's Hospital72 enrolled

Overview

During one-lung ventilation in patients undergoing thoracic surgery, the persistent flow in the non-ventilated lung increases intrapulmonary shunt and decreases systemic arterial oxygenation. This prospective, randomized, double blind study was conducted to evaluate the effects of inhaled iloprost during one-lung ventilation on arterial oxygenation and shunt fraction during thoracic surgery.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Lung Cancer

Interventions

Inhaled iloprostDRUG

Study drug was inhaled to ventilated lung through a nebulized system in inspiratory limb after one-lung ventilation in the lateral decubitus position.

Distilled waterDRUG

Study drug was inhaled to ventilated lung through a nebulized system in inspiratory limb after one-lung ventilation in the lateral decubitus position.

Eligibility

Sex: ALLMin age: 20 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * elective video-assisted thoracoscopic surgery (VATS) lobectomy * 20 \< age \< 75 * American Society of Anesthesiologists (ASA) classification I\~III Exclusion Criteria: * ASA classification IV * New York Heart Association (NYHA) class III\~IV * Severe obstructive lung disease / restrictive lung disease * Pulmonary hypertension * End-stage organ disease (i.e. hepatic failure, renal failure) * Arrhythmia * Previous history of thoracic surgery

Locations (1)

Seoul St.Mary's Hospital

Seoul, South Korea

Outcomes

Primary Outcomes

PaO2(partial pressure of arterial oxygen)

ABGA

Time frame: 30 min after treatment

Pulmonary shunt fraction

Qs/Qt = (CcO2-CaO2) / (CcO2-CvO2)

Time frame: 30 min after treatment

Data from ClinicalTrials.gov

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