Interval Training Versus Electro Acupuncture on Liver Functions in Patients With Non-alcoholic Fatty Liver Disease

Cairo University50 enrolled

Overview

in this study, the investigators compare the effect of interval training exercise and electroacupuncture on liver functions in non-alcoholic fatty liver disease patients

fifty patients suffering from Nonalcoholic fatty liver disease (NAFLD) will be recruited in this study with age ranged from 30-55 years old from both sexes, chosen from internal medicine department at Kasr El Aini hospital and from the outpatient clinic of nutrition and cardiovascular disorders at the faculty of Physical Therapy Cairo University, they were divided in to two groups:Group (1): Twenty-five patients suffering from Nonalcoholic fatty liver disease (NAFLD), and taking their standard medications In addition to electroacupuncture at points of LR3 (Taichong), LR14 (Qimen), GB 34(Yanglingquan) and ST36 (Zu San Li). Group (2): Twenty-five patients suffering from Nonalcoholic fatty liver disease(NAFLD) and taking their standard medications in addition to aerobic interval training exercise.Lab investigations of: Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), Triglycerides (TG) and C-reactive protein (CRP).to judge liver functions

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Non-Alcoholic Fatty Liver Disease

Interventions

aerobic interval training exercise .BEHAVIORAL

Its consisted of cycle ergometer training, 3 days a week for 6 weeks. Aerobic interval training consisted of ( 8 )minutes warm-up, followed by 4 times of 4-minute intervals with HR at 85% of sub maximum HR, with active pauses of 3 minutes of walking at 60% of sub maximum HR. The exercise session was terminated by 5 minutes cool-down

electro acupunctureDEVICE

electroacupuncture (EA) of (2 Hz, 4 mA) was applied at points of:liver 3 LR3,liver 14 LR 14, gall bladder 34 (GB 34) and stomach 36 (ST36) . Duration of the session was 15 min / each, three sessions per week for six weeks

Eligibility

Sex: ALLMin age: 30 YearsMax age: 55 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Sixty patients suffering from Nonalcoholic fatty liver disease (NAFLD). 2. Their age will be ranged from 30-55 years old. 3. Body mass index (30 - 40) 4. All patients are medically stable. Exclusion Criteria: * Patients with Hepatitis C \& b * Acute and chronic significant illnesses that may interfere with actual training, severe ventricular arrhythmia, hemodynamic deterioration or exercise-induced arrhythmia at baseline testing. * Co-morbidities that limit exercise tolerance (hemoglobin 10 g/dl, a chronic obstructive pulmonary disease with FEV1 50%). * Hypertension (resting blood pressure \>140/90 mmHg). * Heart failure, inability to exercise, or drug abuse. * Pacemakers * Pregnancy * Epileptic Seizures * Cancer

Locations (1)

faculty of physical therapy Cairo university

Cairo, Egypt

Outcomes

Primary Outcomes

body mass index

was used for measuring the weight and height of each patient to calculate the body mass index (BMI) (figure). BMI = weight kg / (height m)2

Time frame: about 4 weeks

lab investigations

lab investigation of aminotransferase (ALT) iu/l and Aspartate aminotransferase (AST) iu/l There was a subjective evaluation of the level of exhaustion throw observation of ventilation, walking action and fascial expression in patients at the end stage of test. * Subjects initially performed submaximal exercise stress test (increasing 1 W every 2 s) on an electronically braked cycle ergometer to determine sub maximum heart rate.

Time frame: about 12 weeks

lab investigations

lab investigation of Triglycerides (TG) mg/dl and c-reactive protein mg/l

Time frame: about 14weeks

Data from ClinicalTrials.gov

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