Dotarem Evaluation for Myocardial Perfusion CMR

Aim 1 Inclusion criteria: To be eligible for the study: (All answers must be "YES" for subject to be eligible.) 1. Subject must be referred for a clinically indicated contrast-enhanced stress myocardial perfusion MRI scan out of concern of suspected myocardial ischemia. 2. Subject must be older than 18 years of age. 3. Subject must provide written informed consent prior to any study-related procedures being performed. 4. Subject must be willing to comply with all clinical study procedures. Exclusion Criteria: The presence of the following excludes subjects from the study: (All answers must be "NO" for subject to be eligible.) 1. Subject is a pregnant or nursing female. Exclude the possibility of pregnancy: * By testing (serum or urine beta HCG) within 24 hours before study date, or * By surgical sterilization, or * Post-menopausal, with minimum one (1) year history without menses. 2. Subject has an implanted cardiac pacemaker or implantable defibrillator. 3. Subject has a ferromagnetic vascular clip. 4. Subject has a neurostimulation system (e.g. TENS-Unit). 5. Subject has any type of cochlear implant. 6. Subject has ocular foreign body (e.g. metal shavings). 7. Subject carries any implanted device (e.g. insulin pump, drug infusion device). 8. Subject has shrapnel, bullet, or other type of metal fragments within the body. 9. Subject has an acute psychiatric disorder or is cognitively impaired. 10. Subject is using or is dependent on substances of abuse. 11. Subject is unwilling to comply with the requirements of the protocol. 12. Subject is in acute unstable condition. 13. Subject has an allergy against gadolinium based contrast agents or pharmaceutical stressors used in this study. 14. Subject has impaired renal function (creatinine \> 1.5 mg/dl). 15. Subject presenting with acute coronary syndrome. 16. Positive cardiac enzymes positive troponin, CK-MB, or myosin 17. ST-elevations, new transient ST changes greater than 0.05mV or T- wave inversions with symptoms Aim 2 Inclusion criteria: To be eligible for the study: (All answers must be "YES" for subject to be eligible.) 1. Subject must be referred for a clinically indicated contrast-enhanced stress myocardial perfusion MRI scan out of concern of suspected myocardial ischemia. 2. Subject must be older than 18 years of age. 3. Subject must provide written informed consent prior to any study-related procedures being performed. 4. Subject must be willing to comply with all clinical study procedures. Exclusion Criteria: The presence of the following excludes subjects from the study: (All answers must be "NO" for subject to be eligible.) 1. Subject is a pregnant or nursing female. Exclude the possibility of pregnancy: * By testing (serum or urine beta HCG) within 24 hours before study date, or * By surgical sterilization, or * Post-menopausal, with minimum one (1) year history without menses. 2. Subject has an implanted cardiac pacemaker or implantable defibrillator. 3. Subject has a ferromagnetic vascular clip. 4. Subject has a neurostimulation system (e.g. TENS-Unit). 5. Subject has any type of cochlear implant. 6. Subject has ocular foreign body (e.g. metal shavings). 7. Subject carries any implanted device (e.g. insulin pump, drug infusion device). 8. Subject has shrapnel, bullet, or other type of metal fragments within the body. 9. Subject has an acute psychiatric disorder or is cognitively impaired. 10. Subject is using or is dependent on substances of abuse. 11. Subject is unwilling to comply with the requirements of the protocol. 12. Subject is in acute unstable condition. 13. Subject has an allergy against gadolinium based contrast agents used in this study. 14. Subject has impaired renal function (creatinine \> 1.5 mg/dl).