Combination With Treg Levels and CMR to Assess the Severity and Prognosis of Reperfusion Injury After PPCI in STEMI Patients

Beijing Friendship Hospital250 enrolled

Overview

This study aims to determine whether combination with regulatory T cell (Treg) levels and cardiac magnetic resonance imaging (CMR) are predictive of the severity of reperfusion injury following myocardial infarction and the prognosis in STEMI patients receiving primary percutaneous coronary intervention (PPCI).

Study Type

OBSERVATIONAL

Enrollment

250

Conditions

STEMI - ST Elevation Myocardial Infarction Reperfusion Injury, Myocardial

Interventions

Treg levels and CMR resultsOTHER

This is an observational study. Exposure: Different Treg levels and CMR results.

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * Confirmed STEMI diagnosis * Undergoing primary percutaneous coronary intervention (presenting \<12 hours after symptom onset) * Patients were able to complete cardiac magnetic resonance imaging (CMR) and speckle tracking imaging echocardiogram (STE) examinations * Patients agreed and provided informed consent Exclusion Criteria: * Previous myocardial infarction or revascularization (PCI or CABG) * Congestive heart failure with LVEF\<40% * Atrial fibrillation * Renal insufficiency (GFR \< 30 ml/min/1.73m\^2) * Acute infectious diseases within nearly 3 months * Rheumatic immune system diseases * Malignant tumors * Claustrophobia * Contraindicated to CMR * Patients do not agree to be included in the study

Locations (1)

Beijing Friendship Hospital, Capital Medical University

Beijing, Beijing Municipality, China

RECRUITING

Outcomes

Primary Outcomes

MACE (major adverse cardiovascular events)

nonfatal or fatal myocardial infarction, revascularization, cardiac death, nonfatal or fatal stroke, all cause of death

Time frame: 12 months

Secondary Outcomes

adverse cardiac remodeling

a cut-off value of 12% change in left ventricular end-diastolic volume between the acute and follow-up magnetic resonance scans

Time frame: 6 months

Central Contacts

Hongwei Li, M.D.

CONTACT

0086 10 63139780 lhw19656@sina.com

Data from ClinicalTrials.gov

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