In this observational study researchers want to learn more about changes in visual acuity (clarity of vision) with proactive flexible treatments over time in patients suffering from wet age-related macular degeneration (wAMD) after decision to treat with Aflibercept (Eylea) was made. Wet AMD is an eye disease that progressively destroys the macula, the central portion of the retina, impairing central vision.
Study Type
OBSERVATIONAL
Enrollment
1,563
As prescribed by the treating physician according to the local label. No IVT aflibercept will be provided due to a nature of observational study.
Many Locations
Multiple Locations, Argentina
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Multiple Locations, Australia
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Multiple Locations, Belgium
The change in BCVA (best corrected visual acuity)
In treatment-naïve wAMD patients treated with IVT aflibercept in a flexible proactive treatment pattern (fixed dosing or T\&E (Treat and Extend Regimen)) by label regimen.
Time frame: Baseline to 12 months
The change in BCVA
Time frame: Baseline to 24 and 36 months
The change in BCVA by intended treatment regimen
Time frame: Baseline to 12, 24 and 36 months
The proportion of patients (eyes) gaining or losing a visual acuity compared to baseline
With letter score of ≥ 0 letters, ≥5 letters, ≥ 10 letters, ≥ 15 letters.
Time frame: Baseline at 12, 24 and 36 months
The proportion of patients (eyes) achieving a Snellen equivalent of 20/40 or better (approximately 73 ETDRS letters)
Time frame: At 12, 24 and 36 months
The changes in central retinal thickness (CRT)
Time frame: Baseline to 12, 24 and 36 months
The number of injections
Time frame: Baseline to 12, 24 and 36 months
The distribution of the intervals between injections
Time frame: Up to 36 months
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Many Locations
Multiple Locations, Canada
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Multiple Locations, China
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Multiple Locations, Colombia
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Multiple Locations, Denmark
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Multiple Locations, France
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Multiple Locations, Ireland
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Multiple Locations, Italy
...and 7 more locations