FiO2 and Outcomes After Cardiac Surgery With Cardiopulmonary Bypass

Seoul National University Hospital

Overview

Conventionally, a relatively high level of fraction of inspired oxygen (FiO2) has been used for secure a margin of safety in patients undergoing cardiac surgery using cardiopulmonary bypass (CPB). Since the potential adverse effects of hyperoxemia (via reactive oxygen species, vasocontriction, perfusion heterogeneity, myocardiac injury, etc.), various studies on this topic has been performed. However, the results are conflicting and inconsistent, and the consensus about whether the use of additional oxygen supply in cardiac surgery using CPB has not been reached among practitioners yet.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

TRIPLE

Conditions

Patients Undergoing Cardiac Surgery Using Cardiopulmonary Bypass

Interventions

Fraction of inspired oxygen levelOTHER

A fraction of inspired oxygen level during cardiac surgery using cardiopulmonary bypass will be set differently: 0.5 versus 1.0.

Eligibility

Sex: ALLMin age: 19 Years

Medical Language ↔ Plain English

Inclusion Criteria: * All patients scheduled for cardiac surgery using cardiopulmonary bypass Exclusion Criteria: * Planned implementation of deep hypothermic circulatory arrest * Preoperative respiratory support with the fraction of inspired oxygen of 0.5 and more.

Locations (1)

Seoul National University Hospital

Seoul, South Korea

Outcomes

Primary Outcomes

hospital LOS

length of hospital stay after cardiac surgery using cardiopulmonary bypass

Time frame: From the beginning of surgery until the hospital discharge after surgery through study completion, an expected average of two weeks

Data from ClinicalTrials.gov

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