The Effect of Periodontal Treatment on Psoriasis

Ozge Gokturk92 enrolled

Overview

There is a relationship between psoriasis and periodontal disease. This relationship may be double-sided.

The aim of this randomized controlled clinical study was to determine the effect of non-surgical mechanical periodontal treatment on psoriasis. The study population consisted of 92 periodontitis patients with psoriasis who had untreated periodontal disease. Two randomized groups were formed from these patients. Immediate periodontal treatment (test group, n = 46) and delayed periodontal treatment (control group, n = 46). Clinical periodontal measures, saliva interleukin 2, interleukin 6 and secretory immunoglobulin A levels and PASI scores were performed at baseline and 8th week in control and test group.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

Conditions

Periodontal Diseases

Interventions

Psoriatic measurementsOTHER

Psoriasis Area and Severity Index (PASI) was performed baseline and after 8 weeks. Saliva samples were taken from patients for the evaluation of proinflammatory cytokine baseline and after 8 weeks.

Non-surgical periodontal treatmentOTHER

Non-surgical periodontal treatment was performed baseline and after 8 weeks. Saliva samples were taken from patients for the evaluation of proinflammatory cytokine baseline and after 8 weeks.

saliva samplesOTHER

Saliva samples were taken from patients for the evaluation of proinflammatory cytokine baseline and after 8 weeks.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * the presence at least 20 remaining teeth, * the presence of Stage I or Stage II Periodontitis, * the presence of diagnosed psoriasis. Exclusion Criteria: * patients who had the immune-inflammatory disease and require antibiotic prophylaxis, * patients who received periodontal treatment prior to 6 months, * women who were breastfeeding or pregnant, * patients using medicines such as antibiotics, anti-inflammatory drugs, immune-suppressants.

Locations (1)

Gaziosmanpasa University

Tokat Province, Turkey (Türkiye)

Outcomes

Primary Outcomes

Proinflammatory cytokines

The changes in proinflammatory cytokines levels within 8 weeks. Higher values represent a worse outcome. The decrease in proinflammatory cytokines levels is expected after periodontal treatment.

Time frame: Baseline and after 8 weeks

Secondary Outcomes

Gingival index

The changes in gingival index level after periodontal treatment. Gingival index was measured for determining the severity of disease and clinical outcome. Higher values represent a worse outcome. After periodontal treatment, a reduction in gingival index value is expected.

Time frame: Baseline and after 8 weeks

PASI index

The changes in PASI index level after periodontal treatment. PASI index was measured for determining the severity of psoriasis disease. Higher values represent a worse outcome. After periodontal treatment, a reduction in PASI index value is expected.

Time frame: Baseline and after 8 weeks

Data from ClinicalTrials.gov

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