This study aims at identifying potential new and innovative biomarkers in de novo Parkinson's disease patients. New finding will help phenotyping patients since the diagnosis of the disease and potentially also in the preclinical phase.
The investigators will use 4 different approaches in parallel: 1. detailed clinical evaluation using the current available validated clinical scales and the Dopamine transporter (DAT) SPECT imaging; 2. anatomical and perfusional brain evaluation using functional MRI; 3. cortical brain mapping and transcranial magnetic stimulation assessment using a robotized approach; 4. emotional responses study using a novel paradigm. These 4 modalities will be assessed at baseline, 1 year and 2 years follow-up. The investigators will integrate these 4 analysis using a mathematical paradigm in order to define specific phenotype of disease and disease progression.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
43
3 Tesla brain MRI for structural and perfusion evaluation, resting state analysis and functional MRI
Transcranial magnetic stimulation (TMS) coupled with electroencephalogram (EEG) study
Emotional, attentional and behavioral assessment using predefine scales and measures
CHU Grenoble Alpes
Grenoble, France
To compare cortical excitability differences between subjects
The EEG data after transcranial magnetic stimulation testing will be compared between parkinsonian patients and controls
Time frame: In a seven months period after inclusion
To compare brain structural differences between subjects
All subjects will have a 3 Tesla brain MRI to collect data concerning anatomy. All data will be compared between patients and controls. Brain MRI study will consist in having the following sequences: T1 and T2, Fast Gray Matter Acquisition T1 Inversion Recovery (FGATIR)
Time frame: In a seven months period after inclusion
To compare brain perfusional differences between subjects
All subjects will have a 3 Tesla brain MRI to collect data concerning perfusion. All data will be compared between patients and controls. Brain MRI study will consist in having the following sequences: Pseudo-Continuous Arterial Spin Labeling (PCASL), T2 with gadolinium, FLAIR
Time frame: In a seven months period after inclusion
To compare brain connectivity differences between subjects
All subjects will have a 3 Tesla brain MRI to collect data concerning functional connectivity at rest. All data will be compared between patients and controls. Brain MRI study will consist in having the following sequences: Echo planar imaging (EPI) for the blood oxygen level-dependent effect
Time frame: In a seven months period after inclusion
To compare emotional, attentional and behavior differences between subject
Subjects will be asked to comment on different pictures (if the picture induces pleasure, sorrow or nothing; what would the subjects do). Attentional parameters will be recorded using the Eye tracker.
Time frame: In a seven months period after inclusion
To compare emotional, attentional and behavior differences between subject with functional MRI
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Neurological evaluation, ophthalmologic assessement, Montreal cognitive assessment (MoCA), movement disorder society (MDS)- UPDRS
During a functional MRI study, subjects will be asked to comment on different pictures (if the picture induces pleasure, sorrow or nothing; what would the subjects do). Attentional parameters will be recorded using the Eye tracker.
Time frame: In a seven months period after inclusion