Transmuscular Quadratus Lumborum Block for Postoperative Pain After Laparoscopic Adrenalectomy

Peking Union Medical College Hospital72 enrolled

Overview

This prospective, randomized control study aims to compare the analgesic effect, satisfaction with anesthesia and analgesia between single-injection QLB (quadratus lumborum block)+general anesthesia (GA) and general anesthesia (GA) alone in patients undergoing laparoscopic adrenalectomy.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Pain Management Nerve Block Laparoscopic Adrenalectomy

Interventions

single-injection QLB(quadratus lumborum block)PROCEDURE

Inject 0.4ml/kg 0.5% ropivacaine between quadratus lumborum and psoas major muscle Device: The curved (C1-5) probe of Ultrasound Scanner Philips CX50 is used for scan Drug: single dose ropivacaine 0.4ml/kg 0.5% ropivacaine is given immediately after the correct position of needle tip is verified.

Placebo ControlPROCEDURE

Inject 0.4ml/kg saline between quadratus lumborum and psoas major muscle Device: The curved (C1-5) probe of Ultrasound Scanner Philips CX50 is used for scan Drug: single dose 0.4ml/kg 0.9% NS is given immediately after the correct position of the needle tip is verified

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age 18-70 yrs * American Society of Anesthesiologists physical statusⅠ-Ⅲ * Undergo laparoscopic adrenalectomy * Informed consent Exclusion Criteria: * a known allergy to the medications being used for anesthesia * coagulopathy or on anticoagulants * chronic opioid therapy or history of substance abuse * participating in another RCT * inability to properly describe postoperative pain to investigators (e.g., language barrier, neuropsychiatric disorder).

Locations (1)

Peking Union Medical College Hospital

Beijing, China

Outcomes

Primary Outcomes

the NRS pain scores on activity 12-hours after surgery

The NRS (a number scale from 0 to 10) is a commonly used pain intensity rating tool

Time frame: 12-hours after surgery

Secondary Outcomes

the pain scores at rest determined by the numeric rating scale (NRS, 0-10)

The NRS (a number scale from 0 to 10) is a commonly used pain intensity rating tool

Time frame: At 2,4, 8, 12, 24 ,48,72 hours after the surgery

incidence of postoperative nausea and vomiting (PONV)

Time frame: within 24 postoperative hours

ambulation time

Time frame: within 5 days after surgery

time of recovery of bowel movement

defined as the time to first flatus

Time frame: within 5 days after surgery

postoperative length of hospital stay

Time frame: up to 2 weeks after surgery

patient's satisfaction of anesthesia and analgesia

use the Chinese version of Bauer questionnaire to assess the patient satisfaction of anesthesia

Time frame: 48 hours after surgery

the NRS pain scores on activity after surgery

The NRS (a number scale from 0 to 10) is a commonly used pain intensity rating tool

Time frame: At 2,4, 8, 24 ,48,72 hours after the surgery

Data from ClinicalTrials.gov

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