Central Nervous System (CNS) demyelinating conditions include multiple sclerosis (MS), Acute Disseminated Encephalomyelitis (ADEM), Neuromyelitis Optica Spectrum Disorder (NMOSD), Optic Neuritis (ON) and Transverse Myelitis (TM). The symptoms of these conditions are quite variable from patient to patient, but can include motor, sensory, visual, gait and cognitive changes. Conventional MRI can be used to look for new anatomic changes, but fails to measure underlying biochemical changes in brain tissue. The purposes of this study are to identify the biologic and anatomic correlations between cognitive profiles and disease activity using MRI imaging techniques.
Pediatric patients (age 12 to 21 inclusive) with a diagnosis of multiple sclerosis, ADEM, anti-MOG mediated demyelinating disease as well as healthy controls will be recruited to undergo clinical testing. The study visits will include neuropsychological testing, optical coherence tomography (OCT) and MRI on both the 3T and 7T magnet. Subjects will be asked to undergo two study visits separated by 12 months to 18 months. Each study visit will have the same neuropsychological, OCT, and research MRI examinations.
Study Type
OBSERVATIONAL
Enrollment
49
University Texas Southwestern
Dallas, Texas, United States
MRI Brain without contrast
3T MRI
Time frame: 10-14 months
MRI Brain without contrast
7T MRI
Time frame: 10-14 months
Change in Score of Delis-Kaplan Executive Function System (D-KEFS) Color
Executive Functioning
Time frame: 10-14 months
Change in Score of Word Interference Test (CWIT)
Executive Functioning
Time frame: 10-14 months
Change in Score of Symbol Digit Modalities (SDMT)- Oral Version
Processing Speed
Time frame: 10-14 months
Change in Score of Beery-Buktencia Developmental Test of Visual-Motor Integration, Sixth Edition (VMI-6)
Visual-Motor Integration
Time frame: 10-14 months
Change in Score of Wechsler Intelligence Scale for Children-5th edition (WISCV)
Simple Auditory Attention
Time frame: 10-14 months
Change in Score of Wechsler Adult Intelligence Scale-Fourth edition (WAIS-IV) Digits Forward
Simple Auditory Attention
Time frame: 10-14 months
Change in Score of WISC-V or WAIS-IV Digits Backward
Working Memory
Time frame: 10-14 months
Change in Score of California Verbal Learning Test- Children's Version (CVLT-C) or California Verbal Learning Test-Second Edition (CVLT-II)
Verbal Learning and Memory
Time frame: 10-14 months
Change i Score of D-KEFS Letter and Category Fluency
Verbal Fluency
Time frame: 10-14 months
Change in Score of WASI-II
Estimate of IQ
Time frame: 10-14 months
Change in Score of Woodcock-Johnson Tests of Achievement Letter Word identification
Basic Reading Skill
Time frame: 10-14 months
Change in Score of Reading Fluency
Reading Speed
Time frame: 10-14 months
Change in Score of Calculation
Math Calculation Skills
Time frame: 10-14 months
Change in Score of Math Fluency
Math Speed
Time frame: 10-14 months
Change in Score of Word Attack
Phoneme/Grapheme Knowledge
Time frame: 10-14 months
Change in Score of Grooved Pegboard
Bilateral Fine Motor Speed and Dexterity
Time frame: 10-14 months
Change in Score of Trail Making Test, Part A and B
Simple and complex Attention
Time frame: 10-14 months
Change in Score of Conners Continuous Performance Test 3rd Edition
Sustained Attention and Behavioral Inhibition
Time frame: 10-14 months
Change in Examination of Optical Coherence Tomography
Eye examination
Time frame: 10-14 months
Change in PROMIS Mobility score
Patient Reported Outcomes Measures: Mobility, walking
Time frame: 10-14 months
Change in PROMIS Pain score
Patient Reported Outcomes Measures: overall pain level
Time frame: 10-14 months
Change in PROMIS Peer relationship score
Patient Reported Outcomes Measures: Peer relationships
Time frame: 10-14 months
Change in PROMIS Stress score
Patient Reported Outcomes Measures: Psychological stress
Time frame: 10-14 months
Change in PROMIS Upper extremity movement score
Patient Reported Outcomes Measures: Upper extremity movement
Time frame: 10-14 months
Change in score of 25 foot timed walk
Walking speed
Time frame: 10-14 months
Change in score of 6 minute timed walk
Walking Distance
Time frame: 10-14 months
Change in score of Hauser Ambulation Index
Functional walking assessment
Time frame: 10-14 months
Change in score of Multiple Sclerosis Functional Capacity (MSFC)
Hand and Eye coordination, Memory test
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Time frame: 10-14 months
Change in score of Modified Rankin Scale
Disability scale
Time frame: 10-14 months