Using the therapy of early intervention with Qianyang Yuyin Granules to improve cognitive impairment caused by hypertension.
Using the therapy of early intervention with Qianyang Yuyin Granules to improve cognitive impairment caused by hypertension. The investigators designed a multi-center randomized controlled clinical trial to study the security and effectiveness of this therapy.
Study Type
OBSERVATIONAL
Enrollment
144
Jiangsu Province Hospital of Chinese Medcine
Nanjing, Jiangsu, China
RECRUITINGChanges of brain image
Measure and record the volume changes of diseased alba, the micro-structure changes of alba fasciculus by MRI to see if the therapy effect or not.
Time frame: 24 weeks
Measure and assess the changes of VaDAS-cog ( Vascular Dementia Assessment Scale cognitive subscale ) among time points
Measure and record with VaDAS-cog
Time frame: 12 weeks, 24 weeks, 48 weeks
Measure and assess the changes of MMSE ( Mini-mental State Examination ) among time points
Measure and record with MMSE
Time frame: 12 weeks, 24 weeks, 48 weeks
Measure and assess the changes of ADL ( Activity of Daily Living ) among time points
Measure and record with ADL
Time frame: 12 weeks, 24 weeks, 48 weeks
Measure and assess the changes of CDR ( Clinical Dementia Rating ) among time points
Measure and record with CDR
Time frame: 12 weeks, 24 weeks, 48 weeks
Incidence rate of outcome event
Record the outcome event and analyse the incidence rate
Time frame: 24 weeks
Therapeutic effect
Measure and record patients' systolic and diastolic blood pressure and analyse related data
Time frame: 24 weeks
Metabonomics
Measure and record the metabonomics ( Trx \& TrxR ) index
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Time frame: 24 weeks