Oxygen Concentration During Alveolar Recruitment

Seoul National University Hospital98 enrolled

Overview

The purpose of this study is to investigate the effect of oxygen concentration during alveolar recruitment on absorption ateletasis.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

Atelectasis, Postoperative Pulmonary

Interventions

FiO2_1.0PROCEDURE

Alveolar recruitment is performed with 100% oxygen concentration after general anesthesia induction, after position change to Trendelenburg, after position change to supine, and at the end of operation.

FiO2_0.4PROCEDURE

Alveolar recruitment is performed with 40% oxygen concentration after general anesthesia induction, after position change to Trendelenburg, after position change to supine, and at the end of operation.

Eligibility

Sex: ALLMin age: 20 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients undergoing laparoscopic obstetric or colon surgery with Trendelenburg position Exclusion Criteria: * American Society of Anesthesiologists physical status IV or more * Severe cardiovascular disease * Severe chronic obstructive pulmonary disease, emphysema * History of pneumothorax, bullae * History of lung resection surgery * Conversion to laparotomy * Refusal to participate

Locations (1)

Seoul National University Hospital

Seoul, South Korea

Outcomes

Primary Outcomes

Modified lung ultrasound score

The score is calculated by adding up the 12 individual quadrant scores assessed using lung ultrasound. Each quadrant score ranges from 0 (minimal atelectasis)\~3 (severe atelectasis), so the maximum total score is 36.

Time frame: Intraoperative (at the end of operation, before emergence)

Secondary Outcomes

Modified lung ultrasound score

Time frame: Postoperative 30 minutes

Intraoperative desaturation

Oxygen saturation by pulse oximetry \<95%

Time frame: Intraoperative

Intraoperative partial pressure of arterial oxygen/fraction of inspired oxygen ratio

Partial pressure of arterial oxygen/fraction of inspired oxygen ratio

Time frame: Intraoperative (20minutes after each recruitment)

Postoperative partial pressure of arterial oxygen/fraction of inspired oxygen ratio

Partial pressure of arterial oxygen/fraction of inspired oxygen ratio

Time frame: Postoperative 30 minutes

Postoperative pulmonary complication

respiratory infection, respiratory failure, pleural effusion, atelectasis, pneumothorax, atelectasis, bronchospasm, aspiration pneumonitis

Time frame: Postoperative 24 hours

Data from ClinicalTrials.gov

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