Impact of Antibiotic Prophylaxis in Per-oral Endoscopic Myotomy for Esophageal Motor Disorders

Société Française d'Endoscopie Digestive252 enrolled

Overview

No recommendation regarding antibiotic prophylaxis and preparation modalities are available for patients with esophageal motor disorders who benefit from Per-Oral Endoscopic Myotomy (POEM). The aim of our study was to evaluate the impact of antibiotic prophylaxis on the POEM's safety. This study was a comparative and multicentric retrospective analysis of a database prospectively maintained. Patients over 18 year's old with esophageal motor disorders confirmed by prior manometry, who underwent POEM were included. The primary endpoint was the occurrence of complications, as classified by Cotton, based on whether or not antibiotic prophylaxis was administered.

Study Type

OBSERVATIONAL

Enrollment

252

Conditions

Esophagus Disorder Esophageal Achalasia

Interventions

AntibioticsDRUG

Eligibility

Medical Language ↔ Plain English

Inclusion Criteria: * Adults patients presenting a major esophageal motor disorder confirmed by prior manometry according to the Chicago classification and treated by per-oral endoscopic myotomy after a multidisciplinary meeting decision Exclusion Criteria: * Under-age patients were excluded

Outcomes

Primary Outcomes

The occurence of postoperative complications, according to Cotton's classification

Depending on whether or not antibiotic prophylaxis was administered

Time frame: 7 Days

Secondary Outcomes

The evaluation of the efficacy of the procedure

According to the Eckard score

Time frame: 1 Month

The occurence of perioperative and postoperative complications

According to Cotton's classification

Time frame: 7 Days

The C-Reactive Protein and white blood cells count sampled

Blood test the day after the procedure, level of CRP in mg/L

Time frame: 1 Day