Effect of Charcoal on Gastrointestinal Absorption of Tiotropium

Inclusion Criteria: 1. Written informed consent (IC) obtained. 2. Healthy males and females, aged 18-60 3. Normal weight at least 50 kg. Exclusion Criteria: 1. Evidence of a clinically significant cardiovascular, renal, hepatic, haematological, gastrointestinal, pulmonary, metabolic-endocrine, neurological or psychiatric disease. 2. Any condition requiring regular concomitant treatment (including vitamins and herbal products) or likely to need any concomitant treatment during the study. 3. Any clinically significant abnormal laboratory value or physical finding that may interfere the interpretation of study result or constitute a health risk for the subject if he/she participates in the study. 4. Known hypersensitivity to tiotropium bromide, atropine or its derivatives or to the excipients of the drug. 5. Pregnant or lactating females. 6. Females of childbearing potential not using proper contraception.