Dysfunction of natural koller cells (NK cells) is an important factor in the development of endometriosis. NK cell therapy was applied to treat severe endometriosis, which is an exploration of the pathogenesis of this refractory disease.
Endometriosis (EMs) is one of the common and frequently occurring diseases in women of childbearing age, which seriously affects the health and quality of life of the vast majority of women. The pathogenesis of endometriosis is unknown until now, and the recurrence rate of existing treatment methods is high. It is more and more necessary to introduce new therapeutic methods and strategies in view of the mechanism associated with the reduction of natural killer cell (NK) cytotoxicity. In this study, routine therapy combined with NK cell therapy was used in the treatment of severe endometriosis. The clinical data were collected to confirm the efficacy and safety of NK cell therapy. It is expected to provide a new way of thinking and method for the clinical treatment of EMs.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
60
After conventional treatment, the patients were treated with autologous NK cells.
Postoperative patients were treated with GnRHa combined with reverse addition treatment.
Shenzhen People's Hospital
Shenzhen, Guangdong, China
Incidence of Treatment-Emergent Adverse Events [Safety]
Adverse events will be graded according to the National Cancer Institute Common Terminology Criteria for Adverse Events v4.0
Time frame: 3 months after treatment
Purity and Function of NK cells
The purity and function of NK cells will be measured by flow cytometry.
Time frame: once per three months
Endocrine hormone levels
The levels of endocrine hormone, including serum estradiol, testosterone, progesterone, luteinizing hormone and follicle stimulating hormone will be measured.
Time frame: every three months, up to 36 months
Pain score
A score of 0 means that you have never had this problem, and a score of 100 means that you are always troubled by this problem and feel unbearable. You can choose any number between 0 and 100 to represent your feelings. The higher the score, the worse your feelings will be.
Time frame: every three months, up to 36 months
The percent of pregnancy
The pregnancy will be meaured by B ultrasound.
Time frame: 36 months
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