Cultured Autologous Oral Mucosa Epithelial Sheet for the Treatment of Bilateral Limbal Stem Cell Deficiency

Inclusion Criteria: * Male or female aged ≥ 18 years * Signed and dated informed consent for participation in the study * Total bilateral limbal stem-cell deficiency * Caused by thermal or chemical burn, cornea transplantation, and other bilateral disorders of the ocular surface * Severe loss of vision (\<2/10 on decimal scale or/and EDTRS) * The subject must be covered by a social security system Exclusion Criteria * Eye inflammation * Strictly unilateral ocular affliction * Acute systemic infection, objectified during consultation by the investigator and on the following paraclinical parameter: C Reactive Protein rate * History of acute phase of ocular inflammation in the previous year * History of neoplasic disease * Glaucoma defined as intra ocular pressure (air tonometer and applanation tonometer) ≥ 22mmHg * Total symblepharon (comprising eyelid aperture): impossibility to open the 2 eyes * History of hyper sensibility or allergy to antibiotics or serum * Women who are or may be pregnant or breastfeading * Patients with any active infectious disease (HBV, HCV, HIV, HTLV-1 and syphilis) * Patients who are otherwise ineligible for participation in the study in the opinion of the investigator. * Delay of less than one year after chemical or thermal burns * Person under judicial protection * Contraindication related to anesthesia * Contraindication to fluoresceine * Oral mucosa tumor, pharynx or larynx tumor * Fungal or viral infection of the ENT area * Bacteria infection of the oral mucosa, pharynx or larynx. * Hypersensitivity to ofloxacin (or other quinolone drugs), fluorometholone or betamethasone. * Hypersensitivity to one of the excipients of the eye drops used: Monosodium phosphate, anhydrous disodium phosphate, polysorbate 80, sodium chloride, sodium edetate, polyvinyl alcohol, benzalkonium chloride, hydroxypropylmethylcellulose, hydrochloric acid, sodium hydroxide, lactose, cellulose, crospovidone, aspartam, magnesium stearate, * Phenylketonuria * Psychotic states not yet controlled by treatment; * Vaccination with a live vaccine * Bacterial, fungal, myco-bacterial infection of eye structures. * Some evolving viral infections (including hepatitis, herpes, chickenpox, shingles) or other viral infections of the cornea or conjunctiva (except for a keratitis to Herpes zoster). * Patients treated with Class IA or III antiarrhythmics, tricyclic antidepressants, macrolides and antipsychotics