This study evaluates the gallbladder functions and serum cholecystokinin levels in pregnant women diagnosed with hyperemesis gravidarum. Half of the participants are healthy pregnant women and half of the participants are pregnant women diagnosed with hyperemesis gravidarum. Two groups will be compared by means of gallbladder functions and serum cholecystokinin levels.
Previously gallbladder functions have been observed in human with gallbladder disease. However it has never been evaluated whether there is any difference in gallbladder functions between healthy pregnant women and pregnant women diagnosed with hyperemesis gravidarum. Moreover correlation between hyperemesis gravidarum symptom scores and gallbladder functions has never been assessed. There is also few data comparing serum cholecystokinin levels between healthy pregnant women and those diagnosed with hyperemesis gravidarum. The investigators will measure serum cholecystokinin levels after a fatty meal (100 g chocolate) and compare two groups. In this study the investigators would like to evaluate gallbladder functions and serum cholecystokinin levels in women with hyperemesis gravidarum and compare these with healthy subjects.
Study Type
OBSERVATIONAL
Enrollment
325
Ufuk University Hospital
Ankara, Turkey (Türkiye)
Blood Cholecystokinin (CCK) Levels
a gut hormone released, its level can be measured in blood as fasting level and postprandial
Time frame: Fasting (baseline) and postprandial (15 minutes after the test meal) CCK level
Gallbladder (GB) Wall Thickness
GB wall thickening measured with abdominal ultrasound at fasting and postprandial
Time frame: fasting and postprandial 45th minute
Gallbladder (GB) Volume
volume of GB measured with abdominal ultrasound at fasting and postprandial
Time frame: fasting and postprandial 45th minute
Gallbladder (GB) Ejection Fraction
GB ejection fraction measures how much bile gallbladder releases at one time, expressed as percentage
Time frame: The fasting and postprandial 45th minute
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