The purpose of this study is to evaluate the effect of cytochrome P450 3A4 inhibition by Itraconazole on the pharmacokinetics of BMS-986256.
Study Type
INTERVENTIONAL
Purpose
TREATMENT
Masking
NONE
Enrollment
15
Specified dose on specified days
Specified dose on specified days
PRA Health Sciences - Lenexa
Lenexa, Kansas, United States
Maximum Observed Plasma Concentration (Cmax) of BMS-986256
Time frame: After single dose on Days 1 and 29
Area Under the Plasma Concentration-time Curve from Time Zero to Time of Last Quantifiable Concentration (AUC[0-T]) of BMS986256
Time frame: After single dose on Days 1 and 29
Area Under the Plasma Concentration-time Curve From Time Zero Extrapolated to Infinite Time (AUC[INF]) of BMS-986256
Time frame: After single dose on Days 1 and 29
Percentage of Participants with Adverse Events (AEs)
Time frame: From the time of study treatment administration through the final study visit (Up to 55 days)
Percentage of Participants with Serious Adverse Events (SAEs)
Time frame: From the time ICF is signed through 30 days post dose, or the final study visit (Up to 60 days)
Percentage of Participants with Vital Signs, Electrocardiograms (ECGs), and Physical Examinations Abnormalities
Time frame: From screening to follow-up (Up to 55 days)
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