This study is to Compare the Efficacy and Safety of Rosuvastatin/Amlodipine Combination Therapy Versus Atorvastatin/Amlodipine Combination Therapy in Hypertension patient with Dyslipidemia
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
259
Rosuvastatin 10mg/Amlodipine 5mg qd for 8 weeks
Rosuampin 20/5mg qd for 8 weeks
Amlodipine/Atorvastatin 5/20mg qd for 8 weeks
Daegu Catholic Univ. Medical Center
Daegu, South Korea
Rate of change from baseline to week 8 in LDL-Cholesterol
Time frame: Baseline/Week 8
Rate of change from baseline to week 4 in LDL-Cholesterol
Time frame: Baseline/Week 4
Proportion of subjects who reached the therapeutic goal to week 8
\* Group I: \< 160 mg/dL, Group II: \< 130 mg/dL, Group III: \< 100 mg/dL
Time frame: Week 8
Rate of change from baseline to week 4, 8 in lipid profile(without LDL-C)
Total cholesterol, HDL-C, Triglyceride, Apo A-1, Apo B, Apo B/Apo A-1, Lipoprotein(a)
Time frame: Baseline/Week 4, 8
Rate of change from baseline to week 4, 8 in hs-CRP
Time frame: Baseline/Week 4, 8
Rate of change from baseline to week 4, 8 in glucose index
Fasting Blood Glucose, HbA1C, HOMA-IR
Time frame: Baseline/Week 4, 8
Rate of change from baseline to week 4, 8 in msSBP & msDBP in both arm
Time frame: Baseline/Week 4, 8
Rate of change from baseline to week 4, 8 in difference of msSBP & msDBP in both arm
Time frame: Baseline/Week 4, 8
The incidence of major adverse cardiovascular and cerebrovascular events (MACCE)
Time frame: Week 8
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