Neurocognitive Dysfunction After Anesthesia in Patients With Recent Concussion

Mayo Clinic52 enrolled

Overview

Researchers are trying to determine if the impact of a concussion on the brain is affected by anesthesia and surgery.

All subjects will complete pre and post procedure assessments prior to undergoing a planned surgery/anesthetic standard of care.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Concussion, Brain

Interventions

Neurocognitive TestingOTHER

A comprehensive assessment of neuropsychometric measures to evaluate cognitive functioning.

Eligibility

Sex: ALLMin age: 16 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Male or Female \>16 years of age with a recent concussion (\<10 weeks) from planned procedure under anesthesia. Exclusion Criteria: * Neurologic history including history of severe cognitive disease, disorder, or delay, attention disorder, moderate to severe TBI history, neurovascular order or trauma.

Locations (1)

Mayo Clinic in Rochester

Rochester, Minnesota, United States

Outcomes

Primary Outcomes

Wide Range Achievement Test Fourth Edition, WRAT-4

Change in WRAT-4

Time frame: Pre-anesthetic to one week Post-anesthetic

Secondary Outcomes

Numeric Pain Scale 0-10

Difference in numeric pain scale between the concussion and non-concussion group. Patients verbally select a value that is in line with the intensity of pain they have experienced in the last 24 hours. Pain Scale is recorded "0" = no pain, "10" = the most pain imaginable.

Time frame: Post-operatively to hospital discharge, up to 10 days.

Oral morphine equivalent of consumed opioids

Difference of post-operative opioid use between the concussion and non-concussion group

Time frame: Post-operatively to hospital discharge, up to 10 days.

Length of hospital stay

Difference between the concussion and non-concussion group

Time frame: Post-operatively to hospital discharge, up to 30 days.

Cognitive Deficits identified by NeuroPsychometric Cognitive Testing

Difference between the concussion and non-concussion group.

Time frame: Pre-anesthetic to one week Post-anesthetic

Sport Concussion Assessment Tool - 5th edition, SCAT-5

The SCAT5 is a standardized tool for evaluating concussions designed for use by physicians and licensed medical professionals. Difference in SCAT5 scores between the concussion and non-concussion group. SCAT5 scores the number of symptoms (0-22) present and the severity of symptoms (0-132).

Time frame: Pre-anesthetic to one week Post-anesthetic

Data from ClinicalTrials.gov

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