Embryo DNA Repair Capacity Project

Reproductive Medicine Associates of New Jersey6 enrolled

Overview

The mail aim of the present study is to use molecular methods to analyze the ability of human preimplantation embryos to repair their DNA

The main aim of the present study is to investigate the DNA repair pathways of preimplantation embryos, examining the events that take place following induction of a DSB at a unique targeted site. The investigators aim to address questions concerning the functionality of the DNA repair mechanism(s) in developing embryos, before and after genome activation.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Infertility

Interventions

double strand breakGENETIC

an induction of a double strand break will be made in the embryos generated for this research and the repair mechanism observed

Eligibility

Sex: ALLMin age: 21 YearsMax age: 42 Years

Medical Language ↔ Plain English

Inclusion Criteria: * gamete donors: be at least 21 years of age, in good health and eligible to donate their games through the standard gamete donation programs * IVF couples: any couples proceeding with a routine IVF cycle Exclusion Criteria: * less than 21 years of age * inability to provide informed consent

Locations (1)

Reproductive Medicine Assoicates of New Jersey

Basking Ridge, New Jersey, United States

Outcomes

Primary Outcomes

repair of double strand break in DNA

targeted deep sequencing to identify the presence of the double strand break in the DNA and subsequent repair ability of the embryo

Time frame: up to 12 days

Data from ClinicalTrials.gov

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