Antihypertensives in Non-cardiac Surgical Population

RenJi Hospital351 enrolled

Overview

A cohort of hypertension patients undergoing elective non-cardiac surgery was constructed to investigate current status of antihypertensive drug treatment in non-cardiac surgical population.

Perioperative changes in blood pressure (BP) are associated with perioperative risks. However, there is little information regarding the current status of antihypertensive treatment in non-cardiac surgical population. A cohort of 351 hypertension patients aged between 18 to 85-year old undergoing elective non-cardiac surgery was constructed to investigate the application of antihypertensive drugs, systemic involvement, perioperative hemodynamics and internal environment to grasp the perioperative impact of different antihypertensive drugs, and to further provide a reference for the preoperative antihypertensive strategy of surgery patients.

Study Type

OBSERVATIONAL

Enrollment

351

Conditions

Perioperative Antihypertensive

Eligibility

Sex: ALLMin age: 18 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients undergoing elective non-cardiac surgery with hypertension(i.e., with a systolic blood pressure(SBP) of \>=140 mmHg and/or a diastolic blood pressure(DBP) of \>=90 mmHg based on the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure) or self-reported use of antihypertensive medication Exclusion Criteria: * Patients under the age of 18 years old * Patients more than 85 years old * Patients suspected of intracranial hypertension

Locations (1)

Renji Hospital, Shanghai Jiao Tong University, School of Medicine

Shanghai, Shanghai Municipality, China

Outcomes

Primary Outcomes

perioperative blood press(BP)

baseline BP before the operation, when entering and exiting post-anesthesia care unit(PACU)

Time frame: from the moment on arrival to the operating room until the moment leaving PACU, assessed up to 240 minutes.

Secondary Outcomes

pH, base excess, and concentration of HCO3- in blood gases

arterial blood gases detected by using the ABL800 (Radiometer Med Aps Ltd, Copenhagen, Denmark)

Time frame: 5 minutes after extubating in PACU

the incidence of hypotension in PACU

If there were more than two consecutive episodes of hypotension (which was defined as SBP less than 80% of baseline) a "rescue" intravenous bolus of 100 mg of phenylephrine was given.

Time frame: from the moment on arrival to PACU until 60 minutes after arriving or the moment leaving PACU, whichever came first, assessed up to 240 minutes.

the incidence of hypertension in PACU

the incidence of hypertension, which was defined as SBP greater than 120% of baseline

Time frame: from the moment on arrival to PACU until 60 minutes after arriving or the moment leaving PACU, whichever came first, assessed up to 240 minutes.

hospitalization days

The duration of this single episode of hospitalization

Time frame: from the date of admission until the date of discharge or date of death from any cause, whichever came first, assessed up to 100 days

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.