Evaluation of Intra-Abdominal Fat Extraction Using HydraSolve T2D™ in Obese Subjects With Type 2 Diabetes

Inclusion Criteria: * 1\. Willingness to provide written informed consent. 2\. Willingness and availability to comply with study requirements for the duration of the study, including specific inquiry that the potential subject does not have an impending move or travel planned and can attend the patient visits without undue hardship. 3\. Male or female between 22 - 75 years of age. (Caveat: premenopausal women are excluded) 4\. In good general health except for being diagnosed as having T2D,and in good enough general health to undergo a conversion from a mini-laparotomy to an open laparotomy incision if that conversion becomes necessary during the operative procedure; the subject has no major system disease other than T2D as determined by physical examination, medical history, screening laboratory tests, and EKG. 5\. BMI 30 to 39.9 kg/m2. 6\. Stable body weight during the 6 month time period preceding the anticipated surgery date. (Stable is defined as: the usual baseline body weight of the subject +/- \< 5% change.) 7\. Diagnosis of T2D 10 years or less in duration. 8\. Subject has poorly controlled T2D and is on a current regimen of at least two oral hypoglycemic agents, the first medication dosed at the maximum dose, and the second dosed at the minimum or higher labelled dose. Subject's treatment regime does not include insulin treatment. 9\. HbA1c: 8.0 % - 10.0 %, taken within 30 days pre-op. 10\. Subjects receiving exogenous thyroid hormone, a euthyroid status for at least 3 months prior to enrollment needs to be documented. 11\. Subject agrees to not take any medications that can influence glycemic control unless directed to do so specifically by their physician. 12\. Subject agrees to report all medications they are taking on all case report forms. 13\. Subject agrees to not take any herbal or dietary supplements during the study period. 14\. Subject agrees to not donate blood during the study period. 15\. Subject resides in the San Antonio, TX geographic area. 16\. Subject is able to have MRI examinations. Exclusion Criteria: * 1\. Premenopausal females. 2\. Tobacco use. 3\. Current drug or ETOH abuse. 4\. Uncontrolled psychiatric illness. 5\. Abnormal T4 and TSH found in screening blood test. 6\. Subjects who have contraindications to major abdominal surgery are excluded. 7\. Serum albumin \<35 g/L 8\. Body weight loss \>5% during the 6 month time period preceding the anticipated surgery date. 9\. Presence of a remote body site infection. (Examples: dental urinary, skin soft tissue) 10\. History of cholecystitis, hepatitis or NASH. 11\. History of ulcerative colitis, Crohn's disease, or diverticulitis. 12\. History of respiratory conditions that are not controllable without the use of chronic or intermittent steroid use; such as poorly controlled asthma or COPD. 13\. Chemistry, liver enzyme and function, and hematology levels that are outside of the normal range. (Fasting glucose may be elevated but subject will be excluded if it is ≥ 250 mg/dl.) 14\. LDL ≥ 180 mg/dl. 15\. Triglycerides ≥ 400 mg/dl. 16\. A diagnosis of Cushing's disease. (If a potential subject does not have a diagnosis of Cushing's disease, and the examining endocrinologist detects concerning signs or symptoms that lead him/her to suspect that the potential subject may have Cushing's disease (based on the subject's history, review of systems and physical exam) then that potential subject will be excluded from the study and referred back to his/her primary care physician for further evaluation.) 17\. Anemia, hemoglobinopathy or any conditions that increase red blood cell turnover. 18\. Recent history of receiving a blood transfusion. 19\. Recent history of donating blood. 20\. Clinically significant major organ disease as determined by medical history, physical exam, screening blood tests, urinalysis, and EKG. 21\. History of prior abdominal/pelvic surgery, or prior OB/GYN surgery. 22\. Uncontrolled comorbidity. (Example: uncontrolled hypertension.) 23\. Large umbilical hernia. (This does not include small umbilical hernias that are fat containing only; subjects with this specific type of hernia are allowed in the study, and this type of hernia could be managed and closed primarily with closure of the surgical site.) 24\. Large ventral hernia. 25\. Use of insulin. 26\. Anticoagulation or antiplatelet therapies. 27\. History of gastrointestinal cancer. 28\. Limited life expectancy.