The hypothesis of the study is that in ulcerative colitis repeated flares of inflammatory activity, as well as mechanisms involved in resolution of the inflammatory response, may contribute to accumulation of damage in the colon leading to functional disturbances and symptoms that affect patient's functioning. The primary objective is to determine whether ulcerative colitis induces permanent anatomical damage, by means of magnetic resonance imaging.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
20
A magnetic resonance imaging is perform to detect permanent anatomical damage.
Hospital Galdakao
Galdakao, Bizkaia, Spain
Hospital Reina Sofía
Córdoba, Cordoba, Spain
Hospital Puerta de Hierro
Majadahonda, Madrid, Spain
Hospital Clínic de Barcelona
Barcelona, Spain
Relationship of structural changes in colon morphology and functional changes assessed by MRI with disease duration in UC patients in clinical remission
Explorative structural changes
Time frame: Baseline
Patient reported outcomes on IBDQ-32 questionnaire
Inflammatory bowel diseases health-related quality of life index which is a questionnaire of 32 items, score ranges from 32 to 224.
Time frame: Baseline
Patient reported outcomes on EQ-5D-5L questionnaire
EQ-5D-5L questionnaire a standardized instrument for measuring generic health status, score ranges from -0.224 to 1.
Time frame: Baseline
Patient reported outcomes on Work Productivity and Activity questionnaire
Work Productivity and Activity Impairment questionnaire is a well validated instrument to measure impairments in work and activities. Consists in 6 questions: question1: yes/no, questions 2 to 4: number of hours (count data), question 5: global rating scale, 0-10 (0 = health problems had no effect on my work, 10 = health problems completely prevented me from working), question 6: global rating scale, 0-10 (0 = health problems had no effect on my daily activities, 10 = health problems completely prevented me from doing my daily activities)
Time frame: Baseline
Patient reported outcomes on Disability Index questionnaire
Time frame: Baseline
To identify disease characteristics associated with permanent/accumulated damage disease severity with number of f the hospital admissions
Time frame: Baseline
To identify disease characteristics associated with permanent/accumulated damage disease severity with dose of corticoesteroids
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Time frame: Baseline
To identify disease characteristics associated with permanent/accumulated damage disease severity with dose of immunosuppressants
Time frame: Baseline
To identify disease characteristics associated with permanent/accumulated damage disease severity with dose of biologics drugs
Time frame: Baseline
To identify disease characteristics associated with permanent/accumulated damage with the disease extension at diagnosis and maximal extension of the disease at any time proctitis
Time frame: Baseline
To identify disease characteristics associated with permanent/accumulated damage with the disease extension at diagnosis and maximal extension of the disease at any time left colitis
Time frame: Baseline
To identify disease characteristics associated with permanent/accumulated damage with the disease extension at diagnosis and maximal extension of the disease at any time extensive colitis
Time frame: Baseline
To identify disease characteristics associated with permanent/accumulated damage with the time since the disease diagnosis
Time frame: Baseline
To identify disease characteristics associated with permanent/accumulated damage related to anorectal function using Cleveland Clinic Incontinence Score
Cleveland Clinic Incontinence Score is a questionnaire that reports the consistency and frequency of depositions is a 5 questions questionnaires with 7 possible answers each question.
Time frame: Baseline