Comparison the Effects of 3 Different Intraarticular Ketamine Doses on Postoperative Pain.

Balikesir University75 enrolled

Overview

the aim is to compare the effects of two different doses of intraarticular ketamine on postoperative pain scores and analgesic requirements.in knee artroscopy

All pateints are going to be operated under general anesthesia. At the end of the study patients are going to be randomyl seperated into 3 groups. The surgeon is going the following drugs intraarticulary. Group KL1: 0.5 mg/kg ketamin in % 0..9 NaCl at a total volume of 20 ml Group KL2: 1 mg/kg ketamin in % 0.9 NaCl at a total volume of 20 ml Group SL: 20 ml % 0.9 NaCl ll patients are going to receive a periarticula injection of 10 ml 0.5 bupivacaine and patient controlled analgesia with morphine. VAS scores and total analgesic requirement is going to be evaluated.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

DOUBLE

Enrollment

Conditions

Arthroscopy

Interventions

Ketamine 0.5DRUG

İntrarticular Ketamine 0.5 mg/kg + 0.9 Nacl Total Volume 20 ml

Ketamine 1DRUG

İntrarticular Ketamine 1 mg/kg + 0.9 NaCl Total Volume 20 ml

% 0.9 NaClDRUG

Intraarticular %0.9 NaCl

Eligibility

Min age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Artroscopic surgery * ASA I-II Exclusion Criteria: * Long time NSAID use * Travmatic knee injury * Long ter analgesic use * Intraartiular catheter insertion at the end of surgery

Outcomes

Primary Outcomes

Change in postoperative pain scores throughout time evaluated by VAS

Pain scores are going to be evaluated by VAS scores at rest and VAS scores at activity

Time frame: VAS scores at rest and during activity will be evaluated for 24 hours. The first measurement will be recorded immediately after surgery and at 30 minutes interval for the first hour. Afterwards at 2.4.6.12.24.hours postoperatively.

Difference in opioid Sparing effect measured through morphine amount delivered by a patient controlled analgesia device.

The total amount of morphine delivered by the patient controlled analgesia device in the first 24 hours will be recorded.

Time frame: Total amount off delivered morphine will be recorded for 24 hours.

Secondary Outcomes

Time for discharge measured by eligible for discharge criteria

The time needed to fullfill the dicharge criteria (stable vital signs, able to walk, able to eat, nausea and vomit free, able to mixture)

Time frame: Discharge criterias will be evaluated every three hours until postoperative 24. hour. In patients who did not complete the discharge criteria in the postoperative 24 hours period, they will be defined as prolonged discharge.

Data from ClinicalTrials.gov

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