A Study to Evaluate the DAISe System During Neurointervention for Acute Ischemic Stroke

Inclusion Criteria: * Age 18 to 85 years. * Diagnosis of acute ischemic stroke with study enrollment time \< 8 hours from onset of symptoms. * Disabling stroke defined as a baseline NIHSS \> 6. * Pre-stroke (24 hours prior to stroke onset) independent functional status in activities of daily living with modified Rankin Score 0-1. * If thrombolytic therapy (tPA) is administered, it must be administered per the prescribing information. * Confirmed symptomatic intracranial occlusion, based on single phase, multiphase or dynamic CTA, at one or more of the following locations: Carotid T/L, M1 MCA, or M1-MCA equivalent (2 or more M2-MCAs), or M2-MCA. * The following baseline imaging criteria should be met: MRI criterion: ASPECTS Score \> 4 OR CT criterion: ASPECTS \> 6 * Signed informed consent from patient or legally authorized representative. Exclusion Criteria: * CT or MRI evidence of recent/ fresh hemorrhage on presentation. * Clinical history, past imaging or clinical judgment suggests that the intracranial occlusion is chronic. * Rapidly improving neurological deficits based on the investigator's clinical judgement. * Pregnancy * Severe contrast allergy or absolute contraindication to iodinated contrast. * No femoral pulses or very difficult endovascular access that will result in an inability to deliver endovascular therapy. * Evidence of dissection in the carotid or middle cerebral arteries. * Severe unilateral or bilateral carotid artery stenosis requiring treatment at the time of the procedure as determined during diagnostic angiography. * Renal failure (serum creatinine level ≥ 4 mg/dL or on dialysis). * Severe, sustained hypertension (SBP \>185 mmHg or DBP \>110 mmHg). * Cerebral vasculitis. * Suspicion of aortic dissection, presumed septic embolus or suspicion of bacterial endocarditis. * Clinical symptoms suggestive of bilateral stroke or occlusions in multiple vascular territories (e.g., bilateral anterior circulation, or anterior/posterior circulation). * Seizure due to stroke. * Platelet count \< 50,000/mm3. * A severe or fatal comorbid illness that will prevent improvement or follow-up or that will render the procedure unlikely to benefit the patient. * Patient is unable or unwilling complete follow up visits.