Study of the CAT RX Aspiration Catheter When Used in Patients With Large Occlusive Thrombus in Coronary Arteries

Inclusion Criteria: * Patient age ≥ 18 years * Patient presents to treating facility within 12 hours of symptom onset * High thrombus burden at coronary angiography, defined as TIMI thrombus grade 4 or 5 by physician visual estimate after the guidewire crosses the target lesion * Frontline treatment with the Indigo® Aspiration System using the CAT RX Aspiration Catheter, prior to standard of care PCI * Target lesion is located in a native coronary artery * Informed consent is obtained from either patient or legally authorized representative (LAR) Exclusion Criteria: * New onset of stroke symptoms and NIHSS \> 2, prior to index procedure * Treatment with fibrinolytic therapy for index coronary vessel occlusion * Life expectancy less than 6 months due to any comorbidities * Patient is unwilling or unable to comply with protocol follow up schedule and/or based on the Investigator's judgment the patient is not a good study candidate * Participation in another investigational drug or device study that may confound the results of this study. Studies requiring extended follow-up for products that were investigational but have since become commercially available are not considered investigational studies. * Patient is pregnant