This study will evaluate whether pre-treating patients with Brimonidine 0.2% before and/or after dilating the pupils will help to control the changes in intraocular pressure often seen when using dilating drops. The study will also evaluate the effects of different sequences of administering dilating drops along with Brimonidine on pupil size and reactivity.
Intraocular pressure (IOP) can fluctuate due to various external factors such as exercise, medications, and eye movements. Although it is considered natural for IOP to fluctuate daily, prolonged increases in IOP can be harmful. Sustained elevated IOP has been linked to optic nerve damage and glaucoma. Mydriatic drops routinely given to dilate pupils in patients in need of an eye exam have been known to increase IOP. In practice, a combination of drugs are used to achieve pupil dilation needed for routine eye exams or in perioperative situations. The use of Tropicamide 1% and Phenylephrine 2.5% are known to be safe and effective options for dilating the pupils when used in conjunction with one another, but these drugs can increase IOP. Drugs such as Brimonidine, a selective alpha-2 agonist, are known to reduce IOP through several different methods. This study seeks to understand the effects of Brimonidine used along with Tropicamide and Phenylephrine to control IOP.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
13
2 drops administered once in the left eye in both study arms
1 drop administered at two different times points in both eyes in both study arms
1 drop administered at two different time points in both eyes in both study arms
Wake Forest Baptist Medical Center
Winston-Salem, North Carolina, United States
Intraocular Pressure
To observe how differing the sequence of administration of Tropicamide 1%/Phenylephrine 2.5% and Brimonidine 0.2% influences intraocular pressure.
Time frame: Baseline (Pre drop administration)
Intraocular Pressure
To observe how differing the sequence of administration of Tropicamide 1%/Phenylephrine 2.5% and Brimonidine 0.2% influences intraocular pressure.
Time frame: 15 minutes post drop administration
Intraocular Pressure
To observe how differing the sequence of administration of Tropicamide 1%/Phenylephrine 2.5% and Brimonidine 0.2% influences intraocular pressure.
Time frame: 30 minutes post drop administration
Intraocular Pressure
To observe how differing the sequence of administration of Tropicamide 1%/Phenylephrine 2.5% and Brimonidine 0.2% influences intraocular pressure.
Time frame: 1 hour post drop administration
Intraocular Pressure
To observe how differing the sequence of administration of Tropicamide 1%/Phenylephrine 2.5% and Brimonidine 0.2% influences intraocular pressure.
Time frame: 2 hour post drop administration
Intraocular Pressure
To observe how differing the sequence of administration of Tropicamide 1%/Phenylephrine 2.5% and Brimonidine 0.2% influences intraocular pressure.
Time frame: 4 hour post drop administration
Pupil Size
Pupil size measurement
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Time frame: Baseline (Pre drop administration)
Pupil Size
Pupil size measurement.
Time frame: 15 minutes post drop administration
Pupil Size
Pupil size measurement
Time frame: 30 minutes post drop administration
Pupil Size
Pupil size measurement.
Time frame: 1 hour post drop administration
Pupil Size
Pupil size measurement.
Time frame: 2 hours post drop administration
Pupil Size
Pupil size measurement
Time frame: 4 hours post drop administration
Pupil Reaction to Light
Pupil reaction to light will be measured as none (0), poor (1) or brisk (2).
Time frame: Baseline (Pre drop administration)
Pupil Reaction to Light
Pupil reaction to light will be measured as none (0), poor (1) or brisk (2).
Time frame: 15 minutes post drop administration
Pupil Reaction to Light
Pupil reaction to light will be measured as none (0), poor (1) or brisk (2).
Time frame: 30 minutes post drop administration
Pupil Reaction to Light
Pupil reaction to light will be measured as none (0), poor (1) or brisk (2).
Time frame: 1 hour post drop administration
Pupil Reaction to Light
Pupil reaction to light will be measured as none (0), poor (1) or brisk (2).
Time frame: 2 hours post drop administration
Pupil Reaction to Light
Pupil reaction to light will be measured as none (0), poor (1) or brisk (2).
Time frame: 4 hours post drop administration