Stereotactic Body Radiation Therapy (SBRT) vs Trans-Arterial Chemoembolization (TACE) as Bridge to Transplant

Inclusion Criteria: 1. Subjects with HCC are eligible for this trial. HCC is defined as having at least one of the following: * Biopsy proven HCC or: * A discrete hepatic tumor(s) as defined by the Barcelona (29) criteria for cirrhotic subjects, ≥2cm with arterial hypervascularity and venous or delayed phase washout on CT or MRI. 2. Subjects are liver transplant candidates (actively awaiting organ transplant per transplant services in documentation), or, potential liver transplant candidates (at the discretion of the liver team and/or Principal Investigator) advised by liver transplant services as needing local treatment prior to liver transplant evaluation. 3. Subjects must be within UCSF criteria (one solitary tumor smaller than 6.5 cm, or patients having 3 or fewer nodules, with the largest lesion being smaller than 4.5 cm or having a total tumor diameter less than 8.5 cm without vascular invasion) and eligible for potential liver transplant. 4. Subjects must be eligible per standard of care for either TACE or SBRT procedures. 5. Subjects must have a life expectancy of at least 12 weeks. 6. Subjects must be 18 years of age or older. Adult subjects of all ages, both sexes and all races will be included in this study. 7. Subjects must sign an informed consent form approved for this purpose by the Institutional Review Board (IRB) of record . 8. Subjects must have a Child-Turcotte-Pugh (CTP) score ≤8. 9. Patients must have adequate organ function within 2 weeks of enrollment. * Bone marrow: Platelets ≥30,000/mm3 * Renal: BUN ≤40 mg/dl; creatinine ≤2.0 mg/dl * Hepatic: INR ≤ 1.5 or correctable by Vitamin K, unless anti-coagulated for another medical reason * Bilirubin \< 3.0 mg/dl (in the absence of obstruction or pre-existing disease of the biliary tract, e.g. primary sclerosing cholangitis). 10. Patients uninvolved liver volume will be estimated and must be \> 700ml. 11. Patients must have a Zubrod performance status of ≤2. Exclusion Criteria: 1. Subjects in a "special category" designated by the Public Health Service, Including subjects younger than 18, pregnant women, and prisoners. 2. Refractory ascites that requires paracentesis for management. 3. Known allergy to intravenous iodinated contrast agents unresponsive to prednisone pre-treatment. 4. History of prior radiation to the liver. 5. Evidence of metastatic disease. 6. Presence of a Trans-jugular intra-hepatic porto-systemic shunt (TIPS).