The aim of this observative, prospective study with cross-sectional design is to explore possible correlations/associations between microcirculation parameters and sublingual endothelial glycocalyx in sepsis. Therefore, 30 critically ill septic patients and 10 healthy controls were enrolled.
Study Type
OBSERVATIONAL
Enrollment
40
Non-invasive assessment of endothelial glycocalyx dimensions (PBR) and microcirculatory parameters (e.g. PPV, PVD, TVD, MFI)
Universitiy Hospital Muenster
Münster, Germany
Correlations between Perfused Boundary Region (PBR) and Microvascular Flow Index (MFI) measured sublingually
Glycocalyx thickness will be measured with PBR (in μm) and MFI will be assessed in points. Possible correlations at a given timepoint will be explored (e.g. Spearman's Correlation).
Time frame: During ICU stay, an average of 2 days after sepsis onset
Correlations between Perfused Boundary Region (PBR) and Proportion of Perfused Vessels (PPV) measured sublingually
Glycocalyx thickness will be measured with PBR (in μm) and PPV will be assessed in percentage. Possible correlations at a given timepoint will be explored (e.g. Spearman's Correlation).
Time frame: During ICU stay, an average of 2 days after sepsis onset
Correlations between Perfused Boundary Region (PBR) and Perfused Vessel Density (PVD) measured sublingually
Glycocalyx thickness will be measured with PBR (in μm) and PVD will be assessed in mm/mm\^2. Possible correlations at a given timepoint will be explored (e.g. Spearman's Correlation).
Time frame: During ICU stay, an average of 2 days after sepsis onset
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