Effects of ReWin(d) Supplementation on the Recovery of DOMS Induced by Acute Exercice

Natural Origins40 enrolled

Overview

The study will assess the recovery and performance of young athletes suffering from muscle damage induced by physical exercise. Model by comparing the safety and efficacy of ReWin(d) supplemention during 4 weeks to placebo over 72 hours post exercice.

Double-blind, randomized, placebo controlled, parallel group, pilot safety and efficacy study. 40 healthy young male athetes were randomly assigned to the ReWin(d) or Placebo group. After 4 weeks supplementation (either 2 g daily of ReWin(d) capsules or placebo capsules). the participants were subjected to a 1 hour plyometric exercise session to induce DOMS. At 0 hours, 24 hours, 48 hours and 72 hours post exercise, the volunteers have been assessed to determine: (i) pain perception, (ii) fatigue rate, (iii) sport performance (effectiveness of a jump) and (iv) muscle damage and inflammation by I-R thermography and biomarkers

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Muscle Soreness Delayed-onset Muscle Soreness

Interventions

Polyherbal supplement: ReWin(d) vs PlaceboDIETARY_SUPPLEMENT

Supplementation during 4 weeks + 72 hours post acute exercice

Eligibility

Sex: MALEMin age: 20 YearsMax age: 30 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * \> 18 years old * Young athletes * Training at least 3 times per week * Agree not to initiate any new exercise or diet programs during the entire study period * Agree not to change their current diet or exercise program during the entire study period * Agree not to stretch, utilize ice massage, take anti-inflammatory medications (eg, aspirin, ibuprofen), or use any other treatment for the duration of the trial. Exclusion Criteria: * Previous history of upper extremity injury or knee joint pain * Use of anti-inflammatory medications or pain medications 1 week before the screening visit and during the study * Daily use of dietary supplements and herbal supplements beginning at the screening visit and during the study * Antibiotic use in past 3 months * Chronic disease

Locations (1)

European University of Madrid

Villaviciosa de Odón, Madrid, Spain

Outcomes

Primary Outcomes

Effects of ReWin(d) on muscle recovery induced by physical exercise

Sport performance (effectiveness of a jump) after exercise-induced muscle damage

Time frame: Change from baseline at 0 hours, 24 hours, 48 hours and 72 hours post plyometric exercises session to induce DOMS

Secondary Outcomes

Effects of ReWin(d) on muscle damage induced by physical exercise

Muscle skin temperature monitored by IR-camera.

Time frame: Change from baseline at 0 hours, 24 hours, 48 hours and 72 hours post plyometric exercises session to induce DOMS

Effects of ReWin(d) on pain perception induced by physical exercise

Visual Analogue Scale pain perception after exercise-induced muscle damage

Time frame: Change from baseline at 0 hours, 24 hours, 48 hours and 72 hours post plyometric exercises session

Effects of ReWin(d) on fatigue rate induced by physical exercise

Heart Rate Variability assessment after exercise-induced muscle damage

Time frame: Change from baseline at 0 hours, 24 hours, 48 hours and 72 hours post plyometric exercises session

Effects of ReWin(d) on Gut Microbiota

Determination of Microbiota composition by 16S rRNA Sequencing.

Time frame: Change from baseline dose after 4 weeks of intervention

Data from ClinicalTrials.gov

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