This study is to investigate the oncologic and obstetric outcomes in patients with conization for uterine cervical lesions from January 1, 2000 to January 1, 2019 in Peking Union Medical College Hospital. The primary objectives consist of following: 1. The cumulative incidences of precancerous lesions and cancers of lower genital tract in patients who accepted conization for high grade intraepithelial neoplasia (HSIL), carcinoma in situ and stage IA1 cancer (FIGO 2009) 2. The cumulative pregnancy rates in patients sparing the fertility The secondary objectives consist of following: 1. The effects of surgical protocols (modified Sturmdorf method and "8" figure suture) and energy equipment (cold knife and monopolar electrical cautery) on the oncologic and obstetric outcomes, and on the histological components. 2. A full description of histological components of the conization specimens 3. The cytological and virus outcomes after conization, based on the thin prep liquid-based cytology test (TCT) and high-risk human papillomavirus (HPV) testing
Study Type
OBSERVATIONAL
Enrollment
10,000
High-risk HPV testing for the cytology of lower genital tract
Thin prep liquid-based cytology test for the cytology of lower genital tract
Lei Li
Beijing, Beijing Municipality, China
RECRUITINGThe cumulative incidences of precancerous lesions or cancers
The cumulative incidences of precancerous lesions and cancers of lower genital track in patients who accepted conization for high grade intraepithelial neoplasia (HSIL), carcinoma in situ and stage IA1 cancer (FIGO 2009)
Time frame: Five years
The cumulative pregnancy rates
The cumulative pregnancy rates in patients sparing the fertility
Time frame: Five years
The cytological results after conization
The cytological after conization based on the thin prep liquid-based cytology test (TCT)
Time frame: Five years
The virus outcomes after conization
The virus outcomes after conization high-risk human papillomavirus (HPV) testing
Time frame: Five years
The cumulative pregnancy loss rates
The cumulative pregnancy loss rates in patients sparing the fertility
Time frame: Five years
The cumulative live birth rates
The cumulative live birth rates in patients sparing the fertility
Time frame: Five years
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