Conventional Photodynamic Therapy vs. Painless Photodynamic Therapy for Moderate or Severe Acne

Inclusion Criteria: 1. Clinical diagnosed with moderate to severe acne; 2. Male and female patients of age between 18-30 years old ; 3. All patients read the instructions of the subject, willing to follow the program requirements; 4. No other topical treatment received within 2 weeks prior to enrollment; 5. No systemic treatment was given within 4 weeks prior to enrollment; 6. Patients were unsuitable for surgery for various reasons,unwilling to undergo surgery, and signed informed consent when they had informed other alternatives and agreed to take pictures of the lesion. - Exclusion Criteria: 1. Those who did not complete the informed consent; 2. The lesions belongs to any of the following conditions: There is damage and inflammation, which may lead to the drug entering the open wound; 3. Patients with skin photoallergic diseases, porphyria; 4. Known to have a history of allergies to test drugs (porphyrins) and their chemically similar drugs; 5. Patients with other obvious diseases that may affect the evaluation of efficacy; 6. Scars or patients with a tendency to form scars; 7. Known to have severe immune dysfunction, or long-term use of glucocorticoids and immunosuppressants; 8. Severe heart, liver, kidney disease; with hereditary or acquired People with sexual coagulopathy; 9. Those with severe neurological, psychiatric or endocrine diseases; (10)Women who are pregnant, breast-feeding or using inappropriate contraceptives; those with a history of drug abuse; those who have participated in other drug clinical trials within 4 weeks before treatment.